{"id":"W4296843983","doi":"10.1016/j.euroneuro.2022.07.303","title":"EFFECTS OF CYP2C19, CYP2D6, AND ABCB1 GENE VARIANTS ON ESCITALOPRAM AND ARIPIPRAZOLE TREATMENT-RELATED SEXUAL SIDE EFFECTS: RESULTS FROM THE CAN-BIND-1 STUDY","year":2022,"lang":"en","type":"article","venue":"European Neuropsychopharmacology","topic":"Sexual function and dysfunction studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Centre for Addiction and Mental Health; Royal Ottawa Mental Health Centre; University of British Columbia; University of Guelph; Dalhousie University; University of Toronto; University Health Network; Queen's University; McMaster University","funders":"","keywords":"Escitalopram; Aripiprazole; CYP2C19; CYP2D6; Side effect (computer science); Pharmacology; Medicine; Genetics; Gene; Biology; Internal medicine; Psychiatry; Genotype; Schizophrenia (object-oriented programming); Antidepressant; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004327969,0.0003544015,0.0005060313,0.0001328233,0.0004632169,0.0000223469,0.000130708,0.00003616132,0.00004634962],"category_scores_gemma":[0.0003763421,0.0002556134,0.00005533778,0.0003660102,0.000203708,0.00003772169,0.0002466875,0.0005061048,0.00003131611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005818536,"about_ca_system_score_gemma":0.00004800573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002333908,"about_ca_topic_score_gemma":0.000008995984,"domain_scores_codex":[0.9960762,0.001930347,0.0005550394,0.000819905,0.0003140762,0.000304395],"domain_scores_gemma":[0.9969744,0.002128658,0.0002655345,0.0003837801,0.00006371031,0.0001838899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02932405,0.00753954,0.02959308,0.0000958122,0.003699417,0.008232909,0.01675696,0.0002355787,0.8420124,0.00004547801,0.01629596,0.04616882],"study_design_scores_gemma":[0.041191,0.01978412,0.9170575,0.00001418987,0.001078853,0.0002340458,0.001533575,0.0001008525,0.001447542,0.000009868278,0.01728145,0.0002670054],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901322,0.0008412814,0.000003793537,0.001499133,0.002865343,0.001636441,0.00009778438,0.000181899,0.00274218],"genre_scores_gemma":[0.9921311,0.0002711629,0.00001317599,0.005257197,0.0002725567,0.00008126528,0.00004020072,0.00008774579,0.001845589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8874644,"threshold_uncertainty_score":0.9999896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0180341416155535,"score_gpt":0.2812972746284621,"score_spread":0.2632631330129086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}