{"id":"W4296843983","doi":"10.1016/j.euroneuro.2022.07.303","title":"EFFECTS OF CYP2C19, CYP2D6, AND ABCB1 GENE VARIANTS ON ESCITALOPRAM AND ARIPIPRAZOLE TREATMENT-RELATED SEXUAL SIDE EFFECTS: RESULTS FROM THE CAN-BIND-1 STUDY","year":2022,"lang":"en","type":"article","venue":"European Neuropsychopharmacology","topic":"Sexual function and dysfunction studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Centre for Addiction and Mental Health; Royal Ottawa Mental Health Centre; University of British Columbia; University of Guelph; Dalhousie University; University of Toronto; University Health Network; Queen's University; McMaster University","funders":"","keywords":"Escitalopram; Aripiprazole; CYP2C19; CYP2D6; Side effect (computer science); Pharmacology; Medicine; Genetics; Gene; Biology; Internal medicine; Psychiatry; Genotype; Schizophrenia (object-oriented programming); Antidepressant; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001854177,0.000686735,0.001178245,0.0003544517,0.0003963473,0.0005802609,0.0004150585,0.0008146596,0.002473847],"category_scores_gemma":[0.0031113,0.0004376737,0.002140787,0.0007962275,0.0004473734,0.0005203072,0.0004422653,0.0009229018,0.00026989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003468094,"about_ca_system_score_gemma":0.0003029093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003029336,"about_ca_topic_score_gemma":0.006692528,"domain_scores_codex":[0.9988324,0.0006236751,0.00009244667,0.0001947099,0.000163515,0.00009332942],"domain_scores_gemma":[0.9975395,0.001017731,0.000763951,0.0002401193,0.0001822656,0.0002564436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.09459067,0.002669523,0.8557402,0.0004468841,0.01495204,0.0003873417,0.0003986867,0.0003035754,0.003866792,0.0001144687,0.0006832161,0.02584664],"study_design_scores_gemma":[0.003312956,0.006345546,0.9841743,0.00002766376,0.00459,0.0002369229,0.0001363027,0.0001311557,0.0003464978,0.00004470497,0.0006294393,0.00002457625],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997452,0.001498403,0.00005321554,0.00003891561,0.000009852385,0.00002781858,0.0004512343,0.000002879006,0.0004657454],"genre_scores_gemma":[0.9978929,0.0006258464,0.0001078436,0.00008453899,0.0000222754,0.00002885031,0.0007898398,0.000005190137,0.0004427702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003029336,"threshold_uncertainty_score":0.009805977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0180341416155535,"score_gpt":0.2812972746284621,"score_spread":0.2632631330129086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}