{"id":"W4296844472","doi":"10.1016/j.euroneuro.2022.07.481","title":"INVESTIGATING GENETIC OVERLAP BETWEEN ANTIDEPRESSANTS AND LITHIUM RESPONSE AND TREATMENT RESISTANCE IN MAJOR DEPRESSIVE DISORDER","year":2022,"lang":"en","type":"article","venue":"European Neuropsychopharmacology","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Lithium (medication); Major depressive disorder; Resistance (ecology); Psychology; Clinical psychology; Bipolar disorder; Treatment-resistant depression; Medicine; Psychiatry; Cognition; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008132554,0.0004727735,0.0003937052,0.001031026,0.0005043825,0.000843217,0.0004530417,0.0007960268,0.002909098],"category_scores_gemma":[0.003549933,0.0002681469,0.0007003893,0.001158258,0.0004118408,0.000307259,0.0005615898,0.0005262229,0.0002466892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004359421,"about_ca_system_score_gemma":0.0003717331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004706136,"about_ca_topic_score_gemma":0.005515529,"domain_scores_codex":[0.998572,0.0007365202,0.0001316175,0.0002997635,0.0001519658,0.0001079799],"domain_scores_gemma":[0.9977269,0.0009914655,0.0008378749,0.0001395866,0.0001368487,0.0001672935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001391405,0.0001630628,0.9856419,0.00004897975,0.001052718,0.0007451187,0.0003834302,0.0001386895,0.004591067,0.0001972909,0.0001387027,0.005507704],"study_design_scores_gemma":[0.00004054353,0.0001472218,0.9977881,0.00002131406,0.0002727784,0.0006931598,0.000155593,0.0002823446,0.0002806897,0.0001168445,0.000194442,0.000007000328],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989361,0.00029158,0.0001025704,0.0001112697,0.000007586625,0.000004120923,0.00009811499,0.00000285952,0.0004457714],"genre_scores_gemma":[0.9993662,0.00008455681,0.0001543329,0.00006242516,0.00001079969,0.000005413853,0.00008628541,0.000003838195,0.0002260912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004706136,"threshold_uncertainty_score":0.009731889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01941205866785315,"score_gpt":0.2934252332467932,"score_spread":0.27401317457894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}