{"id":"W4296888765","doi":"10.1016/j.bbrc.2022.09.069","title":"The insufficiency of Dlx5 for ventral patterning in post-migratory neural crest cells reveals a loss of plasticity in early jaw-forming tissue","year":2022,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; University of Guelph","keywords":"DLX5; Neural crest; Biology; Cranial neural crest; Anatomy; Fate mapping; Hindbrain; Branchial arch; Neuroscience; Cell biology; Progenitor cell; Homeobox; Central nervous system; Embryo; Gene; Genetics; Stem cell; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002148467,0.0004635193,0.000404929,0.000621132,0.0003139272,0.0008785404,0.0006405041,0.0006499967,0.00291361],"category_scores_gemma":[0.000279093,0.0003655668,0.0004464332,0.0002734856,0.0006256698,0.0005184892,0.0006107617,0.001263271,0.0009364956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004372823,"about_ca_system_score_gemma":0.0003990386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001659896,"about_ca_topic_score_gemma":0.00242958,"domain_scores_codex":[0.9996019,0.00003859884,0.00007725612,0.00008195209,0.0001028733,0.00009756064],"domain_scores_gemma":[0.9994882,0.0001086451,0.00009063364,0.00009707235,0.00002869541,0.000186617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005687574,0.000007711026,0.0002586413,0.00001860312,0.000004583776,0.0001028615,0.000007801043,0.00003326203,0.998929,0.0001059412,0.00001447122,0.0004602908],"study_design_scores_gemma":[0.000008767081,0.00004699249,0.01054578,0.000005876372,0.00001814237,0.0005403262,0.00005034793,0.0005813821,0.9866489,0.0000546284,0.001494336,0.000004455092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920168,0.001288677,0.003812664,0.0001708305,0.00004491782,0.00001330374,0.0007795239,0.0001436529,0.001729605],"genre_scores_gemma":[0.9940099,0.0002372178,0.001139894,0.00008274263,0.000005427028,0.00001356785,0.000720391,0.00007412497,0.003716846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00291361,"threshold_uncertainty_score":0.009747028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03102644332169819,"score_gpt":0.3341000300956256,"score_spread":0.3030735867739274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}