{"id":"W4296888765","doi":"10.1016/j.bbrc.2022.09.069","title":"The insufficiency of Dlx5 for ventral patterning in post-migratory neural crest cells reveals a loss of plasticity in early jaw-forming tissue","year":2022,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; University of Guelph","keywords":"DLX5; Neural crest; Biology; Cranial neural crest; Anatomy; Fate mapping; Hindbrain; Branchial arch; Neuroscience; Cell biology; Progenitor cell; Homeobox; Central nervous system; Embryo; Gene; Genetics; Stem cell; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000465401,0.00006547287,0.000112343,0.00005671625,0.0002171127,0.00000667818,0.0004470925,0.0000601438,0.000001308847],"category_scores_gemma":[0.0002194075,0.00005361861,0.00003734592,0.0002279704,0.0005598242,0.000004459791,0.0005690824,0.0002256402,2.870611e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002329352,"about_ca_system_score_gemma":0.00007393573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001053438,"about_ca_topic_score_gemma":0.00006177148,"domain_scores_codex":[0.9989988,0.0002180217,0.0002527064,0.0001652331,0.0001452048,0.0002200398],"domain_scores_gemma":[0.9992123,0.0003254342,0.00006392503,0.0002612524,0.00009764334,0.00003950113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001802853,0.0003651181,0.00681387,0.00002057005,0.000006999192,2.793801e-7,0.0001347351,0.00000665317,0.9899555,0.0002635394,0.0000383627,0.002214036],"study_design_scores_gemma":[0.0004035506,0.0008702921,0.1106624,0.00002199056,0.00000338374,0.000001662387,0.0003006274,0.0004444874,0.8859408,0.0002498225,0.001007292,0.00009363441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986634,0.0005450813,0.00001393593,0.0004042302,0.00001389371,0.0002638025,0.00007494446,0.000001514277,0.0000192591],"genre_scores_gemma":[0.9994003,0.0001661882,0.0001735644,0.0000164831,0.00001285698,0.0001044327,0.00009608685,0.00000463579,0.00002549218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1040147,"threshold_uncertainty_score":0.2186503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03102644332169819,"score_gpt":0.3341000300956256,"score_spread":0.3030735867739274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}