{"id":"W4296897435","doi":"10.3389/ftox.2022.991590","title":"Integrated Genotoxicity Testing of three anti-infective drugs using the TGx-DDI transcriptomic biomarker and high-throughput CometChip® assay in TK6 cells","year":2022,"lang":"en","type":"article","venue":"Frontiers in Toxicology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada","funders":"National Institute of Environmental Health Sciences; Health Canada; Canada Research Chairs","keywords":"Genotoxicity; Biology; DNA damage; Biomarker; Transcriptome; Genetics; Gene; DNA; Chemistry; Toxicity; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000897755,0.001086211,0.001169007,0.000884681,0.0002876968,0.0007024756,0.0006178345,0.001114514,0.001427893],"category_scores_gemma":[0.0006848765,0.0004153429,0.001065563,0.000769028,0.0004105078,0.0005133856,0.0005471441,0.001220615,0.0009803823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004226755,"about_ca_system_score_gemma":0.000448803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001223197,"about_ca_topic_score_gemma":0.002487138,"domain_scores_codex":[0.9983402,0.000161217,0.0001692862,0.0004706248,0.0007482732,0.0001104594],"domain_scores_gemma":[0.9993365,0.0001377792,0.0001514726,0.00008384702,0.0002441202,0.000046256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005570866,0.00003921788,0.0006767689,0.0001213256,0.00001538606,0.00003608386,0.00004014987,0.0002300656,0.9962202,0.00004324896,0.00007963795,0.002442264],"study_design_scores_gemma":[0.000006223907,0.0004043891,0.003178614,0.00001100254,0.00003553959,0.00008174352,0.00003170373,0.001730208,0.9931186,0.00004669137,0.001334631,0.00002058834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8570939,0.003336643,0.1216559,0.0003449461,0.0002746259,0.0008705225,0.009192556,0.0022197,0.005011067],"genre_scores_gemma":[0.816195,0.003398118,0.1511951,0.0004435385,0.00004143041,0.001812413,0.01443956,0.0002774029,0.01219743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001427893,"threshold_uncertainty_score":0.004776776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01978868581967922,"score_gpt":0.2498318984772206,"score_spread":0.2300432126575414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}