{"id":"W4296902187","doi":"10.1016/s0140-6736(22)01588-4","title":"Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial","year":2022,"lang":"en","type":"article","venue":"The Lancet","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":193,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; McMaster University; Population Health Research Institute","funders":"McMaster University; Bayer","keywords":"Medicine; Placebo; Ischaemic stroke; Stroke (engine); Double blind; Internal medicine; Acute stroke; Cardiology; Ischemia; Tissue plasminogen activator; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001148784,0.00207334,0.003728026,0.0003610604,0.0003581043,0.001375947,0.0007472083,0.00184299,0.006310808],"category_scores_gemma":[0.001226776,0.0006090048,0.002166079,0.0004869391,0.000997474,0.001059736,0.0003677888,0.003485779,0.0009502282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000595968,"about_ca_system_score_gemma":0.0007838839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001233588,"about_ca_topic_score_gemma":0.00249403,"domain_scores_codex":[0.999655,0.0001410449,0.00002402986,0.00006839311,0.00002619096,0.0000852087],"domain_scores_gemma":[0.9996305,0.0001114293,0.00008415258,0.00002733244,0.00002700926,0.0001195971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9702291,0.002133587,0.000363167,0.002004554,0.002214837,0.00005869558,0.00005000726,0.0002181034,0.001954299,0.0002177958,0.001735115,0.01882075],"study_design_scores_gemma":[0.9863955,0.01141353,0.0007549515,0.00004979324,0.0004730396,0.00003196678,0.00001632341,0.0001226891,0.0001315783,0.0001337081,0.0004676864,0.000009198526],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9470436,0.03815563,0.001380024,0.001811915,0.002103005,0.003001564,0.001270936,0.0003429818,0.004890386],"genre_scores_gemma":[0.9598897,0.021813,0.002129508,0.002640463,0.001075783,0.004292394,0.001306857,0.00004512713,0.006807275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006310808,"threshold_uncertainty_score":0.02111179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03692745211021783,"score_gpt":0.3158417623479136,"score_spread":0.2789143102376958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}