{"id":"W4296905190","doi":"10.1016/j.jaci.2022.09.013","title":"Epigenetic and immunological indicators of IPEX disease in subjects with FOXP3 gene mutation","year":2022,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children; Institute of Infection and Immunity","funders":"Stanford Maternal and Child Health Research Institute; California Department of Public Health","keywords":"FOXP3; Immunology; Immune dysregulation; Enteropathy; Medicine; Autoimmunity; Immune system; Biology; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001592072,0.0001898515,0.0002198557,0.0004918053,0.0002988367,0.0003363695,0.0001709303,0.0003548306,0.001549387],"category_scores_gemma":[0.0007447625,0.0001006514,0.0001886727,0.0004009945,0.0002287718,0.000200895,0.000169381,0.0002926195,0.0001416296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001295521,"about_ca_system_score_gemma":0.000108662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008114042,"about_ca_topic_score_gemma":0.0008404091,"domain_scores_codex":[0.9998889,0.00001890583,0.00001004363,0.00003399245,0.0000181075,0.00003008082],"domain_scores_gemma":[0.9997544,0.00006142711,0.00009745564,0.00001804315,0.00002771191,0.00004087634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001381745,0.0001423121,0.9664336,0.00003282469,0.00009111319,0.002493446,0.0003149273,0.0001000371,0.01975214,0.0001242835,0.000182716,0.008950856],"study_design_scores_gemma":[0.00001414779,0.0002436686,0.9943196,0.000008794964,0.00008549265,0.00285815,0.0002415151,0.000291227,0.001356999,0.0001697758,0.0004038439,0.000006800222],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990067,0.0002543665,0.0001119112,0.0000461055,0.000009157381,0.00000480357,0.00009615123,0.000004798849,0.0004660558],"genre_scores_gemma":[0.9995255,0.00005880273,0.00006278895,0.00002628652,0.00001377841,0.000004126131,0.00006793651,0.000001910164,0.0002387239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001549387,"threshold_uncertainty_score":0.00518322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01324712936379023,"score_gpt":0.260552519846199,"score_spread":0.2473053904824088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}