{"id":"W4296905415","doi":"10.1016/j.eururo.2022.09.003","title":"Predictive Biomarkers in Muscle Invasive Bladder Cancer: Are We There Yet?","year":2022,"lang":"en","type":"letter","venue":"European Urology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Alberta Cancer Foundation; Princess Margaret Cancer Centre","funders":"EMD Serono; Eisai Canada; Astellas Pharma Canada; Janssen Pharmaceuticals; Bayer; AstraZeneca; Bristol-Myers Squibb","keywords":"Medicine; Prostate cancer; Bladder cancer; Cancer; Risk assessment; Prostate; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00018675,0.000525561,0.0007446863,0.0003841139,0.0001035451,0.00001661376,0.0003796423,0.0003518937,0.007364113],"category_scores_gemma":[0.00007495948,0.0004754993,0.0002244685,0.0003183865,0.0002212322,0.00004733717,0.0002751523,0.00234746,0.0002643359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003767502,"about_ca_system_score_gemma":0.0004119134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004452762,"about_ca_topic_score_gemma":0.0002164452,"domain_scores_codex":[0.9964716,0.001062728,0.0004340527,0.0009736517,0.0003814527,0.0006764524],"domain_scores_gemma":[0.9986079,0.0002360661,0.0002986315,0.0006794309,0.00006561422,0.0001123889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000583916,0.0001262038,0.007723582,0.0001320419,0.001335484,0.02046079,0.0007684369,0.0000196566,0.0000366383,0.000001552183,0.9661664,0.002645272],"study_design_scores_gemma":[0.002872915,0.001457316,0.04065542,0.0001161241,0.0006069861,0.0001415333,0.0002065769,0.000006894096,0.00001469418,0.00005095985,0.9535264,0.0003441783],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.007926865,0.01471039,0.000005917116,0.8575687,0.002477547,0.001654701,0.001261007,0.0002343448,0.1141605],"genre_scores_gemma":[0.06985342,0.005627272,0.00002418,0.9106485,0.003790921,0.0004022992,0.0008840007,0.0004289381,0.008340498],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1058201,"threshold_uncertainty_score":0.9999542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02783545083460224,"score_gpt":0.2649945253372427,"score_spread":0.2371590745026404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}