{"id":"W4296930416","doi":"10.1101/2022.09.14.507904","title":"The SARS-CoV-2 spike N-terminal domain engages 9- <i>O</i> -acetylated α2-8-linked sialic acids","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Alberta","funders":"National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Universiteit Utrecht; European Commission; Bill and Melinda Gates Foundation","keywords":"Glycan; Avidity; Sialic acid; Receptor; Chemistry; Binding domain; Binding site; Biochemistry; Plasma protein binding; Amino acid; Biology; Molecular biology; Glycoprotein; Genetics; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007742735,0.0003126707,0.0001563725,0.00006314087,0.00008964274,0.0002062962,0.000154055,0.0002006415,0.0006931928],"category_scores_gemma":[0.00007442127,0.00009051831,0.0002597039,0.00009045273,0.000110519,0.0001318206,0.0001636405,0.000216832,0.0002371867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002062484,"about_ca_system_score_gemma":0.0001076559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008579869,"about_ca_topic_score_gemma":0.00104498,"domain_scores_codex":[0.9999073,0.00001289529,0.000004973845,0.00001836102,0.00002990053,0.00002660758],"domain_scores_gemma":[0.9999698,0.000003137499,0.000007550438,0.00000494762,0.000005766255,0.000008901445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002741361,0.000006233464,0.0002590789,0.000006850156,0.000002128299,0.00002650141,0.000003906244,0.00003164222,0.9994167,0.00002483118,0.00001068777,0.0001840945],"study_design_scores_gemma":[0.000004577036,0.000188261,0.006250777,0.000003388368,0.000006832536,0.0002451152,0.00003297289,0.001329788,0.9908293,0.00002089227,0.001083498,0.000004452414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982463,0.00012998,0.0007685669,0.00001881556,0.000006321245,0.000006528654,0.0001165295,0.00001192955,0.0006950665],"genre_scores_gemma":[0.997321,0.00009082666,0.001044913,0.00003916597,0.000002350776,0.000005319062,0.0004275566,0.000004871535,0.001064053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008579869,"threshold_uncertainty_score":0.002318978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03562547391933474,"score_gpt":0.3059304914674504,"score_spread":0.2703050175481157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}