{"id":"W4296964702","doi":"10.1016/s2152-2650(22)00886-2","title":"Poster: CML-046 Dose Modification Dynamics of Ponatinib in Patients With Chronic-Phase Chronic Myeloid Leukemia From the PACE and OPTIC Trials","year":2022,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Myeloid leukemia; Ponatinib; Medicine; Pace; Oncology; Internal medicine; Nilotinib; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002127188,0.0003882287,0.0009221898,0.0001946718,0.0002808869,0.000909234,0.0002907953,0.0005397041,0.009245683],"category_scores_gemma":[0.003756559,0.0001454276,0.001291945,0.0002847011,0.0002211124,0.0007121151,0.0004421365,0.001650891,0.001231699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007595739,"about_ca_system_score_gemma":0.001124309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006289995,"about_ca_topic_score_gemma":0.001585207,"domain_scores_codex":[0.9994374,0.0002521693,0.00004409721,0.00008926199,0.0000958716,0.00008120656],"domain_scores_gemma":[0.9990351,0.0003068306,0.0002260184,0.00008555261,0.0001008806,0.0002455663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3030963,0.003468197,0.02070415,0.001368542,0.002498847,0.0001576986,0.0002487018,0.00797496,0.01067641,0.001843211,0.1110249,0.5369381],"study_design_scores_gemma":[0.2597354,0.1579166,0.2825259,0.0005501569,0.005764008,0.001224119,0.0003730626,0.01282561,0.01542664,0.008008893,0.2553584,0.0002911768],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9102394,0.01262368,0.002130334,0.01485642,0.001300906,0.001361598,0.02331562,0.0003524648,0.03381949],"genre_scores_gemma":[0.9668345,0.003872362,0.002496663,0.004500264,0.0008404782,0.0008120156,0.01135031,0.0001192155,0.009174202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009245683,"threshold_uncertainty_score":0.03092992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03591066286180756,"score_gpt":0.3327238929423084,"score_spread":0.2968132300805009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}