{"id":"W4296982306","doi":"10.1002/ana.26511","title":"Amyloid‐Related Imaging Abnormalities in the <scp>DIAN‐TU</scp>‐001 Trial of Gantenerumab and Solanezumab: Lessons from a Trial in Dominantly Inherited Alzheimer Disease","year":2022,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Intracerebral and Subarachnoid Hemorrhage Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; McGill University; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Avid Radiopharmaceuticals; National Institutes of Health; GHR Foundation; F. Hoffmann-La Roche; Roche; National Institute on Aging; Eli Lilly and Company; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Medicine; Internal medicine; Odds ratio; Confidence interval; Placebo; Dementia; Oncology; Gastroenterology; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003152088,0.0004687131,0.000801852,0.0001327148,0.000227862,0.0005011759,0.0002473909,0.0005183341,0.0007692688],"category_scores_gemma":[0.001727115,0.0001582482,0.0005940189,0.0001482289,0.0003721902,0.0003556444,0.0001544751,0.0007867796,0.00009428892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002944194,"about_ca_system_score_gemma":0.0003608333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004552007,"about_ca_topic_score_gemma":0.001243562,"domain_scores_codex":[0.998926,0.0007239031,0.00008068266,0.0001129933,0.00008462595,0.00007170661],"domain_scores_gemma":[0.9987212,0.0005094582,0.0003155858,0.00006714284,0.00009375514,0.0002928677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7728202,0.004831312,0.09846409,0.0006956389,0.004390427,0.0003834653,0.0003219853,0.0003623277,0.0237445,0.0002131811,0.00141622,0.09235653],"study_design_scores_gemma":[0.2314689,0.2997861,0.4492672,0.0002954817,0.00495498,0.001819607,0.0003060512,0.002341849,0.005577078,0.0004843102,0.003629826,0.0000686145],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980204,0.001416721,0.00005230342,0.0001349129,0.00002320687,0.00003604888,0.00003616203,0.000003863472,0.0002763422],"genre_scores_gemma":[0.999086,0.0003554553,0.0001338713,0.0001401384,0.00004201311,0.00004187295,0.00007709205,0.000001667208,0.0001217901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003152088,"threshold_uncertainty_score":0.01667005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06638678835487119,"score_gpt":0.3437128231605561,"score_spread":0.2773260348056849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}