{"id":"W4296992824","doi":"10.3390/bioengineering9100496","title":"Targeting Capabilities of Native and Bioengineered Extracellular Vesicles for Drug Delivery","year":2022,"lang":"en","type":"review","venue":"Bioengineering","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nanocarriers; Extracellular vesicles; Targeted drug delivery; Drug delivery; Nanotechnology; Extracellular vesicle; Biocompatibility; Drug; Chemistry; Biology; Microvesicles; Materials science; Pharmacology; Cell biology; microRNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005605398,0.0007865214,0.0008233885,0.001677752,0.0001914799,0.0009596239,0.0005920576,0.001109656,0.001506801],"category_scores_gemma":[0.0004716615,0.0003065147,0.0004851031,0.001122579,0.0003724478,0.001293292,0.0006148782,0.001197951,0.001070957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006032153,"about_ca_system_score_gemma":0.0006831465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00074433,"about_ca_topic_score_gemma":0.001133312,"domain_scores_codex":[0.9998417,0.00002754123,0.00001865825,0.00002670454,0.00006163829,0.00002370236],"domain_scores_gemma":[0.9998513,0.00007951676,0.00001904368,0.000004955363,0.00003336496,0.00001175735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007050201,0.00007134688,0.0001275636,0.01830809,0.00008061279,0.0002942286,0.00008059525,0.0007575497,0.01164183,0.01183004,0.01360231,0.9431353],"study_design_scores_gemma":[0.00001005684,0.0001157966,0.0003738774,0.002088384,0.00005999549,0.000950942,0.00003678993,0.0001633038,0.004213012,0.001322635,0.9906427,0.00002241244],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000284099,0.9980159,0.0002458575,0.0001323893,0.0001182724,0.000005175186,0.00001653531,0.000006647466,0.001175092],"genre_scores_gemma":[0.001459535,0.9973286,0.0002920434,0.000103071,0.00005718912,0.000008658582,0.00002772747,0.000001729952,0.0007214344],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001677752,"threshold_uncertainty_score":0.005040765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01928503976422464,"score_gpt":0.2584476874908433,"score_spread":0.2391626477266187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}