{"id":"W4296992824","doi":"10.3390/bioengineering9100496","title":"Targeting Capabilities of Native and Bioengineered Extracellular Vesicles for Drug Delivery","year":2022,"lang":"en","type":"review","venue":"Bioengineering","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nanocarriers; Extracellular vesicles; Targeted drug delivery; Drug delivery; Nanotechnology; Extracellular vesicle; Biocompatibility; Drug; Chemistry; Biology; Microvesicles; Materials science; Pharmacology; Cell biology; microRNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003813707,0.0004355999,0.0007620727,0.000161279,0.00007936067,0.00002053716,0.0003171122,0.0001842225,0.00002113265],"category_scores_gemma":[0.0002648857,0.0004574364,0.0003924264,0.0001329731,0.00010472,0.000006471701,0.0002625901,0.0001725011,5.849261e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005343385,"about_ca_system_score_gemma":0.0001388255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006828125,"about_ca_topic_score_gemma":6.757341e-7,"domain_scores_codex":[0.9983062,0.00007077614,0.0005790626,0.0005315031,0.0001518857,0.0003606394],"domain_scores_gemma":[0.9990891,0.0001305119,0.000233983,0.0003805554,0.00005271229,0.0001131444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000103744,0.0003078609,0.00002009912,0.1266409,0.002042203,0.00003910076,0.0005951899,0.001993047,0.169953,0.0009377105,0.002550306,0.6948168],"study_design_scores_gemma":[0.0002175172,0.00009258332,5.571028e-7,0.0007276868,0.0003191481,0.00001150276,0.0001864437,0.0005149394,0.005328323,0.00001645511,0.9920543,0.0005305066],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003694816,0.992949,0.00177482,0.000003132719,0.0002386233,0.0008153445,0.0004754635,0.00003481958,0.00001398669],"genre_scores_gemma":[0.002399202,0.9924948,0.003434765,0.000003200979,0.0002385926,0.0003238046,0.0007802652,0.0001377256,0.0001876232],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.989504,"threshold_uncertainty_score":0.9997877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01928503976422464,"score_gpt":0.2584476874908433,"score_spread":0.2391626477266187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}