{"id":"W4297001332","doi":"10.3390/curroncol29100540","title":"Crosstalk between Immune Checkpoint Modulators, Metabolic Reprogramming and Cellular Plasticity in Triple-Negative Breast Cancer","year":2022,"lang":"en","type":"review","venue":"Current Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cancer Research Institute","keywords":"Triple-negative breast cancer; Reprogramming; Crosstalk; Cancer research; Immune checkpoint; Medicine; Breast cancer; Immune system; Immunology; Biology; Cell biology; Cancer; Computational biology; Immunotherapy; Genetics; Gene; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000361131,0.0006047549,0.0008725928,0.001345666,0.0002273694,0.000820907,0.0005483151,0.0008887736,0.0021136],"category_scores_gemma":[0.0003874872,0.0001855216,0.0003332492,0.00109689,0.0003125661,0.0008418486,0.0005855355,0.001487176,0.001044085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005483021,"about_ca_system_score_gemma":0.0007329006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006238558,"about_ca_topic_score_gemma":0.001457179,"domain_scores_codex":[0.9999037,0.00001982746,0.00001312879,0.00001612179,0.0000328262,0.00001451458],"domain_scores_gemma":[0.9998616,0.00005790651,0.0000199734,0.000003488401,0.00003842799,0.0000185888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001033919,0.00007133375,0.0003090139,0.01390487,0.00009321304,0.0003269463,0.00006543699,0.0003851235,0.003267956,0.004369217,0.03102508,0.9460784],"study_design_scores_gemma":[0.00001535108,0.0001235349,0.001147807,0.002625278,0.0001090432,0.001719699,0.00006142067,0.0001302294,0.00104003,0.002322976,0.9906856,0.00001890068],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000130484,0.9987705,0.00008791158,0.0002609443,0.000172111,0.000002381058,0.00001082472,0.000005448113,0.0005593878],"genre_scores_gemma":[0.0009135131,0.9981716,0.000105319,0.0001785927,0.0001811586,0.000004415581,0.00002443862,0.000001047604,0.0004199425],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0021136,"threshold_uncertainty_score":0.00707072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08336944757964389,"score_gpt":0.3901919443714755,"score_spread":0.3068224967918316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}