{"id":"W4297016153","doi":"10.1126/sciimmunol.abo3170","title":"Dysregulated stem cell niches and altered lymphocyte recirculation cause B and T cell lymphopenia in WHIM syndrome","year":2022,"lang":"en","type":"article","venue":"Science Immunology","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Lymphopoiesis; Biology; Immunology; Mesenchymal stem cell; Stem cell; Bone marrow; Haematopoiesis; Stromal cell; Progenitor cell; Lymphocyte; Cancer research; B cell; Interleukin-7 receptor; Hematopoietic stem cell; T cell; Cell biology; IL-2 receptor; Immune system; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006744602,0.0004705279,0.0002212971,0.0005584164,0.0001018137,0.0001576521,0.0001159954,0.0002958062,0.001340718],"category_scores_gemma":[0.0001099767,0.0001606221,0.0001796235,0.0001673178,0.0002953784,0.0001080325,0.0002387758,0.0003427039,0.0002460956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001260064,"about_ca_system_score_gemma":0.000101074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002938823,"about_ca_topic_score_gemma":0.0005286308,"domain_scores_codex":[0.9999096,0.00001686871,0.00001178713,0.00002126365,0.00002413922,0.00001620813],"domain_scores_gemma":[0.9999157,0.00001496976,0.00003358701,0.000005814947,0.000004087348,0.00002582773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001220861,0.00001489725,0.002399113,0.00002747316,0.000009680865,0.002185281,0.00003409852,0.00009927975,0.9931092,0.0001363373,0.00004874955,0.001813786],"study_design_scores_gemma":[0.0001540609,0.001014796,0.11228,0.00003726091,0.0001369447,0.04121827,0.0002873161,0.003037384,0.8363311,0.0005576127,0.004920769,0.00002448706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983523,0.0003639179,0.0007576134,0.0000267121,0.000003883315,0.000006995668,0.0001274675,0.00004617092,0.0003149576],"genre_scores_gemma":[0.9980806,0.0002669367,0.0008473774,0.00002926344,0.000005048529,0.00001636734,0.0001317809,0.00001556121,0.0006070849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001340718,"threshold_uncertainty_score":0.00448513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01283608674101629,"score_gpt":0.2333104470371101,"score_spread":0.2204743602960938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}