{"id":"W4297019170","doi":"10.3233/jad-220766","title":"Loss of Cholinergic Receptor Muscarinic 1 (CHRM1) Protein in the Hippocampus and Temporal Cortex of a Subset of Individuals with Alzheimer’s Disease, Parkinson’s Disease, or Frontotemporal Dementia: Implications for Patient Survival","year":2022,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"","keywords":"Hippocampus; Temporal cortex; Dementia; Cholinergic; Frontotemporal dementia; Alzheimer's disease; Internal medicine; Cerebral cortex; Muscarinic acetylcholine receptor; Neuroscience; Medicine; Cortex (anatomy); Psychology; Endocrinology; Disease; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010966,0.0002272931,0.0002389161,0.0004927729,0.0002287842,0.0002082587,0.0001497843,0.0002122056,0.0006398805],"category_scores_gemma":[0.0002028925,0.0001000651,0.000113937,0.0001938502,0.0001879233,0.0001396672,0.0001034604,0.0001605896,0.0001771538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001683266,"about_ca_system_score_gemma":0.000119416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002063126,"about_ca_topic_score_gemma":0.002493987,"domain_scores_codex":[0.9999491,0.000004187674,0.00000503269,0.00001800743,0.00001485798,0.000008832243],"domain_scores_gemma":[0.9999219,0.000007627063,0.0000318655,0.000005577865,0.00001575562,0.00001729216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002193308,0.0001755291,0.669847,0.0001200505,0.0001761894,0.003081695,0.0002921023,0.0001053327,0.3026198,0.00005752565,0.000671668,0.02065984],"study_design_scores_gemma":[0.000014856,0.0001787577,0.9871034,0.000006575151,0.00005689883,0.006338029,0.0001574336,0.0001751217,0.005603536,0.00004280192,0.0003193478,0.000003204051],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990055,0.0005785616,0.00008517998,0.00001883596,0.000003407995,0.000004041872,0.0001219064,0.000005460819,0.0001770378],"genre_scores_gemma":[0.9990416,0.0003433717,0.0001813549,0.00002178874,0.00000699915,0.00000482994,0.0001891762,0.000001252136,0.0002096242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002063126,"threshold_uncertainty_score":0.00410229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02285425108920557,"score_gpt":0.2826830905184484,"score_spread":0.2598288394292428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}