{"id":"W4297063097","doi":"10.1101/gad.14.7.854","title":"Severe liver degeneration and lack of <i>NF</i>-κ<i>B</i> activation in <i>NEMO/IKKγ</i>-deficient mice","year":2000,"lang":"en","type":"article","venue":"Genes & Development","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":478,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); University of Toronto; Ontario Institute for Cancer Research","funders":"Deutsche Forschungsgemeinschaft","keywords":"IκB kinase; Phosphorylation; Biology; Kinase; IκBα; NF-κB; Cell biology; Molecular biology; Transcription factor; Mutant; Tumor necrosis factor alpha; NFKB1; Apoptosis; Signal transduction; Cancer research; Biochemistry; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001944998,0.0001492411,0.0001318373,0.00005039744,0.00005864018,0.00001467965,0.00009510994,0.000111579,0.00004952375],"category_scores_gemma":[0.000009274971,0.0001534879,0.00002569859,0.0001092468,0.00003325698,0.000006840065,0.00005645399,0.00004840641,0.00001351075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003214428,"about_ca_system_score_gemma":0.0001338614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003246863,"about_ca_topic_score_gemma":0.00009671968,"domain_scores_codex":[0.9989808,0.0000453646,0.0002934591,0.0003282786,0.0001579964,0.0001940647],"domain_scores_gemma":[0.9996495,0.000008429778,0.00007338761,0.0001610124,0.00006124852,0.00004646785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006569393,0.00006961184,0.00211433,0.0000317694,0.00001471587,0.000001339559,0.0003789276,0.0008523817,0.9425306,0.00001760346,0.0003533249,0.0535697],"study_design_scores_gemma":[0.0004579372,0.00005370404,0.004784704,0.00003154592,0.000005822771,0.000009328511,0.00003851641,0.00005033537,0.9545116,0.00001337003,0.03984239,0.0002006764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973294,0.001116856,0.0005781306,0.00005008512,0.00004811465,0.0001947056,0.000005246855,0.000009032442,0.0006684428],"genre_scores_gemma":[0.9916763,0.0004979915,0.006714349,0.0003793447,0.00005534697,0.00002695321,0.0001465507,0.00001751241,0.0004855982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05336902,"threshold_uncertainty_score":0.6259053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01927967264655892,"score_gpt":0.2319802482506923,"score_spread":0.2127005756041334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}