{"id":"W4297065898","doi":"10.3390/antibiotics11101277","title":"Guanidinylated Polymyxins as Outer Membrane Permeabilizers Capable of Potentiating Rifampicin, Erythromycin, Ceftazidime and Aztreonam against Gram-Negative Bacteria","year":2022,"lang":"en","type":"article","venue":"Antibiotics","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Polymyxin; Aztreonam; Ceftazidime; Colistin; Microbiology; Polymyxin B; Antibiotics; Rifampicin; Bacteria; Gram-negative bacteria; Chemistry; Pharmacology; Biology; Antibiotic resistance; Imipenem; Biochemistry; Pseudomonas aeruginosa; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003289199,0.0003391797,0.0004375669,0.0001032564,0.0003622979,0.00004974289,0.0003260144,0.0001802401,0.0001742908],"category_scores_gemma":[0.0001945256,0.0003545987,0.0001492809,0.0002506197,0.0003415807,0.00001732305,0.0004618775,0.0002286506,0.000007178659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004731374,"about_ca_system_score_gemma":0.0001601186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001992263,"about_ca_topic_score_gemma":0.00004385367,"domain_scores_codex":[0.9977684,0.000191408,0.0005538916,0.0006505596,0.0003048651,0.0005308679],"domain_scores_gemma":[0.998705,0.00004685975,0.0003711919,0.0005834295,0.0001590989,0.0001344246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001936426,0.0001573508,0.03228312,0.00009528997,0.0002001472,0.00002540759,0.0003844951,0.0001065891,0.9656632,0.0001316716,0.0004731499,0.0002859396],"study_design_scores_gemma":[0.001568444,0.0009408915,0.0358584,0.00007294669,0.000125949,0.000113871,0.002852031,0.0003383029,0.9542529,0.0001083379,0.003086027,0.0006819006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971064,0.0002919424,0.00007205474,0.0001660945,0.0004108185,0.0003506171,0.0001861137,0.00003036894,0.001385589],"genre_scores_gemma":[0.9950087,0.0004159799,0.002548663,0.0003851897,0.00009344777,9.563984e-7,0.0003315504,0.00006990064,0.001145577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0114103,"threshold_uncertainty_score":0.9998906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0066969515556424,"score_gpt":0.226994567672966,"score_spread":0.2202976161173236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}