{"id":"W4297065898","doi":"10.3390/antibiotics11101277","title":"Guanidinylated Polymyxins as Outer Membrane Permeabilizers Capable of Potentiating Rifampicin, Erythromycin, Ceftazidime and Aztreonam against Gram-Negative Bacteria","year":2022,"lang":"en","type":"article","venue":"Antibiotics","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Polymyxin; Aztreonam; Ceftazidime; Colistin; Microbiology; Polymyxin B; Antibiotics; Rifampicin; Bacteria; Gram-negative bacteria; Chemistry; Pharmacology; Biology; Antibiotic resistance; Imipenem; Biochemistry; Pseudomonas aeruginosa; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001048814,0.0002648356,0.0001171984,0.0001032432,0.00005469209,0.0001117866,0.00009838936,0.0001651557,0.0004719686],"category_scores_gemma":[0.0001001139,0.00008036894,0.00009135512,0.00009480462,0.0001310355,0.0001366638,0.0001536478,0.0003643712,0.0001281117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001028381,"about_ca_system_score_gemma":0.00009360557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000197085,"about_ca_topic_score_gemma":0.000397423,"domain_scores_codex":[0.9999392,0.00001868847,0.000004256435,0.00001066958,0.00001506035,0.00001209573],"domain_scores_gemma":[0.9999472,0.000006970692,0.00001972027,0.000005953656,0.000006598738,0.00001371274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006054723,0.00001819395,0.00005342617,0.00003563043,0.000002478814,0.00002597633,0.000006150168,0.0000736877,0.9971602,0.00007499008,0.00001771435,0.002471025],"study_design_scores_gemma":[0.00002077062,0.0004593355,0.001521866,0.000008228939,0.000009602584,0.0001714562,0.000006857018,0.0003182293,0.9940231,0.00002875038,0.003427872,0.000003896711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869822,0.006842681,0.003598486,0.0001299778,0.00003742876,0.00005108504,0.00009824836,0.00006052773,0.002199476],"genre_scores_gemma":[0.9923233,0.00266214,0.003536652,0.00004535537,0.00001236681,0.00001774271,0.0001006612,0.00001000485,0.001291813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004719686,"threshold_uncertainty_score":0.001578927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0066969515556424,"score_gpt":0.226994567672966,"score_spread":0.2202976161173236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}