{"id":"W4297094033","doi":"10.1097/ppo.0000000000000616","title":"Targeting HRAS in Head and Neck Cancer","year":2022,"lang":"en","type":"article","venue":"The Cancer Journal","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"HRAS; Farnesyltransferase; Cancer research; Mutant; Head and neck squamous-cell carcinoma; Head and neck; Head and neck cancer; Prenylation; Mutation; Cancer; Medicine; KRAS; Biology; Internal medicine; Gene; Enzyme; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002742067,0.0002782253,0.000299479,0.0003397357,0.0001589656,0.0004365096,0.0003335541,0.0003091001,0.00285575],"category_scores_gemma":[0.0001157816,0.0001081614,0.000202843,0.0003042398,0.0002003452,0.000206415,0.0002473564,0.0005916134,0.0006896014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007956719,"about_ca_system_score_gemma":0.000570667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001376274,"about_ca_topic_score_gemma":0.003149726,"domain_scores_codex":[0.9998949,0.00001080434,0.000007428938,0.00001429924,0.00003665611,0.00003592237],"domain_scores_gemma":[0.9999522,0.000005478885,0.00001049206,0.00000716559,0.00001018088,0.00001453752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002362301,0.0004407838,0.005244888,0.0007710141,0.0001076842,0.0007364038,0.00005586613,0.001273456,0.7214175,0.002231641,0.006265518,0.259093],"study_design_scores_gemma":[0.0006868643,0.004152399,0.02766747,0.0001162977,0.0002993033,0.007860813,0.0001075754,0.002410312,0.8418232,0.00109459,0.1137494,0.00003171753],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.81069,0.1520777,0.007698947,0.003293918,0.0005469392,0.0004488735,0.001578921,0.0006595166,0.02300513],"genre_scores_gemma":[0.9574589,0.03202249,0.003911005,0.0004606245,0.00007412785,0.0001050298,0.0008654156,0.00002008608,0.005082289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00285575,"threshold_uncertainty_score":0.009553432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02396064067901938,"score_gpt":0.3258756078887202,"score_spread":0.3019149672097008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}