{"id":"W4297094033","doi":"10.1097/ppo.0000000000000616","title":"Targeting HRAS in Head and Neck Cancer","year":2022,"lang":"en","type":"article","venue":"The Cancer Journal","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"HRAS; Farnesyltransferase; Cancer research; Mutant; Head and neck squamous-cell carcinoma; Head and neck; Head and neck cancer; Prenylation; Mutation; Cancer; Medicine; KRAS; Biology; Internal medicine; Gene; Enzyme; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003511644,0.00005490828,0.0001260314,0.0000746085,0.0002794331,0.0000193746,0.00005634042,0.00001065858,0.004777918],"category_scores_gemma":[0.00001740403,0.00003678182,0.00004587652,0.000203527,0.00002952083,0.00003639361,0.00004424504,0.0004870205,0.000001887898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002085458,"about_ca_system_score_gemma":0.0001344016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000389749,"about_ca_topic_score_gemma":0.0001359648,"domain_scores_codex":[0.9993519,0.00006754394,0.0001581966,0.00008329975,0.000193254,0.0001458701],"domain_scores_gemma":[0.9997489,0.00001497392,0.00007150332,0.00006217473,0.00002852149,0.0000739245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008714625,0.0002873738,0.7126695,0.00009610631,0.0004131387,0.0007908327,0.00762431,0.01808091,0.07201344,0.0002228875,0.1331058,0.05382429],"study_design_scores_gemma":[0.022114,0.0007955108,0.5309684,0.003029377,0.0007827387,0.00420221,0.01875626,0.02987345,0.005320811,0.004002779,0.3790585,0.00109594],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756481,0.00474869,0.00001777651,0.01894311,0.00006471411,0.00004867794,0.000009572975,0.000007025624,0.0005123023],"genre_scores_gemma":[0.993498,0.001049247,0.00003271005,0.004186802,0.0004207491,0.00002611657,0.000002055966,0.000007927065,0.0007763456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2459528,"threshold_uncertainty_score":0.9961318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02396064067901938,"score_gpt":0.3258756078887202,"score_spread":0.3019149672097008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}