{"id":"W4297149170","doi":"10.3390/cancers14194640","title":"Lin28 Regulates Cancer Cell Stemness for Tumour Progression","year":2022,"lang":"en","type":"review","venue":"Cancers","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; U.S. Department of Defense","keywords":"LIN28; Reprogramming; microRNA; Cancer stem cell; Cancer research; Regulator; Biology; Suppressor; Translation (biology); Stem cell; Prostate cancer; Cancer; Cell; Cell biology; Messenger RNA; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002789406,0.0005000224,0.0005558936,0.000966343,0.00020377,0.0007125642,0.0004614064,0.0006237526,0.004359182],"category_scores_gemma":[0.0003039713,0.0001684376,0.000299463,0.0007284561,0.0002444085,0.000683098,0.0004860376,0.001222262,0.002264252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000481849,"about_ca_system_score_gemma":0.0007065065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005056459,"about_ca_topic_score_gemma":0.001019652,"domain_scores_codex":[0.9999201,0.00001125385,0.000009200188,0.00001433045,0.00003540252,0.000009689121],"domain_scores_gemma":[0.999916,0.00003374572,0.00001227435,0.000003282799,0.00002264006,0.00001207845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008106787,0.00005150221,0.0001608538,0.008998993,0.00006482924,0.0001813346,0.00004522411,0.0004033234,0.007756781,0.006646906,0.02647289,0.9491363],"study_design_scores_gemma":[0.00001059842,0.0000459624,0.0004271558,0.0008469389,0.00003700244,0.0006070964,0.00001671324,0.00007420944,0.001220401,0.001470146,0.9952356,0.000008184362],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003208651,0.9962944,0.0002650281,0.0003057334,0.0002223448,0.000006170126,0.00003186878,0.00001765649,0.002535829],"genre_scores_gemma":[0.001766961,0.9959669,0.0002598503,0.0002202788,0.0001203322,0.000008880739,0.00006312662,0.000003344434,0.001590315],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004359182,"threshold_uncertainty_score":0.01458293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04846944645344541,"score_gpt":0.3864304033040087,"score_spread":0.3379609568505633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}