{"id":"W4297154498","doi":"10.1101/2022.09.25.509394","title":"HNF1α transcriptional activation and repression maintain human islet α and β cell function","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institutes of Health; Howard Hughes Medical Institute","keywords":"Biology; Hepatocyte nuclear factors; HNF1A; Islet; Cell biology; Transcription factor; Downregulation and upregulation; Psychological repression; Haploinsufficiency; Genetics; Phenotype; Endocrinology; Gene; Insulin; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001157101,0.0001479613,0.0001029461,0.00009216291,0.00008429607,0.000218757,0.0000958895,0.0001028242,0.0007446096],"category_scores_gemma":[0.0000869939,0.00008054294,0.00009404307,0.00006041894,0.0001399483,0.00007876604,0.0001023637,0.0002301736,0.0002429239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001827417,"about_ca_system_score_gemma":0.0001193772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005848383,"about_ca_topic_score_gemma":0.0005213417,"domain_scores_codex":[0.9999416,0.000006036045,0.000005186992,0.00002417808,0.00001187155,0.00001100371],"domain_scores_gemma":[0.9999325,0.00001041064,0.00001797675,0.00001686956,0.000008599884,0.00001361328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003938597,0.000005944896,0.0002372421,0.000005206488,0.00000151166,0.00001370746,0.000005718612,0.00003942754,0.998933,0.00004146082,0.00001223062,0.0006650784],"study_design_scores_gemma":[0.000007349951,0.0001175997,0.007772249,0.000003306904,0.00000684007,0.0002096709,0.00002072158,0.001122861,0.9890542,0.00006199077,0.001621266,0.000002039669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942998,0.0004029941,0.00419205,0.00002744798,0.00001160013,0.00001076965,0.0003332261,0.00007765651,0.0006443983],"genre_scores_gemma":[0.9955062,0.0002787706,0.002024674,0.00002385071,0.000005027321,0.00001548958,0.000539668,0.00002100248,0.001585355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007446096,"threshold_uncertainty_score":0.002490997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152958135389372,"score_gpt":0.2265947135388881,"score_spread":0.2112988999999509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}