{"id":"W4297175913","doi":"10.1007/s40620-022-01465-z","title":"Clinical characteristics and outcomes of a patient population with atypical hemolytic uremic syndrome and malignant hypertension: analysis from the Global aHUS registry","year":2022,"lang":"en","type":"article","venue":"Journal of Nephrology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Akershus Universitetssykehus; Alexion Pharmaceuticals; AstraZeneca","keywords":"Atypical hemolytic uremic syndrome; Medicine; Eculizumab; Thrombotic microangiopathy; Internal medicine; Nephrology; Incidence (geometry); Kidney disease; Transplantation; Gastroenterology; Pediatrics; Disease; Complement system; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001149689,0.000279367,0.0005682478,0.000945274,0.0002534435,0.0005926255,0.0003363815,0.0003794441,0.0007276037],"category_scores_gemma":[0.002460215,0.00021672,0.0006597083,0.001720053,0.0002739579,0.0005981797,0.0007514857,0.0004485148,0.000122565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002405066,"about_ca_system_score_gemma":0.0003160172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002887721,"about_ca_topic_score_gemma":0.002782366,"domain_scores_codex":[0.999225,0.0002574496,0.0001011972,0.0002036681,0.000121517,0.00009116268],"domain_scores_gemma":[0.9981577,0.000290135,0.001022121,0.0001723556,0.0001275336,0.0002302055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001318044,0.00001232336,0.9989843,0.00001102029,0.0000864664,0.00003559889,0.00002522388,0.00004798355,0.00004759448,0.00001418984,0.0001354667,0.0004678721],"study_design_scores_gemma":[0.00001282885,0.00005712579,0.999352,0.000005502854,0.00004959536,0.0001516724,0.00006734794,0.0001398735,0.00001642529,0.00001814627,0.0001264664,0.000003000007],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972983,0.0003173423,0.00008664296,0.00005392924,0.000006318,0.00001454276,0.001796579,0.000005497556,0.0004209754],"genre_scores_gemma":[0.9979478,0.00012482,0.00005819639,0.00003288102,0.00001174172,0.00002220987,0.001755708,0.000002621735,0.00004413242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002887721,"threshold_uncertainty_score":0.00608021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01627332798369483,"score_gpt":0.2631696711431889,"score_spread":0.2468963431594941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}