{"id":"W4297216396","doi":"10.1093/dote/doac051.315","title":"315. PATIENT-DERIVED ESOPHAGEAL ADENOCARCINOMA ORGANOIDS TREATED WITH CHEMOTHERAPEUTIC AGENTS MAY PREDICT TUMOR RESPONSE IN VIVO","year":2022,"lang":"en","type":"article","venue":"Diseases of the Esophagus","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Medicine; Paclitaxel; Irinotecan; Cisplatin; Internal medicine; Oncology; Taxane; In vivo; Adenocarcinoma; Esophageal cancer; Neoadjuvant therapy; Gastroenterology; Cancer; Chemotherapy; Colorectal cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004527114,0.0002214322,0.0003215766,0.000350187,0.0001350414,0.000467595,0.00009605871,0.0002616614,0.001781083],"category_scores_gemma":[0.0005653296,0.0001428399,0.0002227183,0.0002651542,0.0001477028,0.0001867938,0.0002116937,0.0003196635,0.0007857711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002516485,"about_ca_system_score_gemma":0.0001061278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006116538,"about_ca_topic_score_gemma":0.0004925728,"domain_scores_codex":[0.9997879,0.00005968138,0.0000215272,0.00006062839,0.00004683373,0.00002338396],"domain_scores_gemma":[0.9996511,0.0001071688,0.00007452589,0.00004862802,0.00006077187,0.00005791011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003589269,0.0002620423,0.1888289,0.0001013967,0.00008012412,0.0002292319,0.000152646,0.002799187,0.7904323,0.00007104273,0.0005021747,0.01295163],"study_design_scores_gemma":[0.00008577305,0.00584594,0.5522888,0.00001858725,0.0001352485,0.001402022,0.0004025678,0.01654638,0.4197126,0.0001196239,0.003410131,0.00003225034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965591,0.0003872772,0.001349257,0.0000297087,0.00001226227,0.00003679487,0.0009545744,0.00004961539,0.0006214405],"genre_scores_gemma":[0.9967721,0.00008976497,0.00109974,0.00002150242,0.000002678576,0.00003388578,0.00158019,0.000006578249,0.0003934388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001781083,"threshold_uncertainty_score":0.005958319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01208399725009284,"score_gpt":0.260495037547571,"score_spread":0.2484110402974781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}