{"id":"W4297235752","doi":"10.1101/2022.09.24.509328","title":"Gene regulatory changes underlie developmental plasticity in respiration and aerobic performance in highland deer mice","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"High Altitude and Hypoxia","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; National Institutes of Health; National Science Foundation","keywords":"Biology; Hypoxia (environmental); Developmental plasticity; Peromyscus; Phenotypic plasticity; Phenotype; Stressor; Gene expression; Gene; Transcriptome; Respiration; Deer mouse; Plasticity; Genetics; Zoology; Neuroscience; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000147838,0.0001952394,0.000146108,0.0004484876,0.0001155295,0.0002214865,0.0001544092,0.0002183799,0.001715705],"category_scores_gemma":[0.0001300384,0.0001889417,0.0002287133,0.0001753459,0.0003076648,0.0001046525,0.0002354357,0.0004132404,0.0002193084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001496077,"about_ca_system_score_gemma":0.00009314922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005295716,"about_ca_topic_score_gemma":0.001008824,"domain_scores_codex":[0.9998589,0.00001758347,0.00001184219,0.00005559736,0.00002285161,0.0000332841],"domain_scores_gemma":[0.9997832,0.00003541252,0.00008867712,0.00002785543,0.00001775277,0.00004709256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001693517,0.00001517357,0.002672097,0.000011513,0.000006055729,0.00004378968,0.00002192279,0.00003170543,0.996367,0.00004490656,0.00002960244,0.000586818],"study_design_scores_gemma":[0.0000457495,0.0003911228,0.3547032,0.00001495558,0.00004818572,0.0009526468,0.0002449812,0.0009105676,0.6405221,0.0001694045,0.001980428,0.00001669468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972601,0.0001264091,0.001205012,0.00003229001,0.00000463028,0.000006397713,0.00107627,0.00003327976,0.000255575],"genre_scores_gemma":[0.9932174,0.0001839624,0.001939164,0.00007799325,0.000007642358,0.00005370784,0.001563074,0.00005615494,0.002900871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001715705,"threshold_uncertainty_score":0.005739629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01389823312681974,"score_gpt":0.2091169483091834,"score_spread":0.1952187151823636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}