{"id":"W4297238478","doi":"10.1107/s2053230x22008810","title":"The structure of succinyl-CoA synthetase bound to the succinyl-phosphate intermediate clarifies the catalytic mechanism of ATP-citrate lyase","year":2022,"lang":"en","type":"article","venue":"Acta Crystallographica Section F Structural Biology Communications","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"ATP citrate lyase; Lyase; Allosteric regulation; Mutant; Citric acid cycle; Enzyme; Chemistry; Stereochemistry; Acetyl-CoA; Active site; Catalytic cycle; Biochemistry; Citrate synthase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007086908,0.0003648804,0.0002543966,0.0001350644,0.0002687067,0.0004032039,0.0003563019,0.0005929631,0.001107703],"category_scores_gemma":[0.0001667606,0.0002059208,0.0003076281,0.0002440354,0.0002853669,0.0004071326,0.0001996398,0.0008348532,0.0005419796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005001799,"about_ca_system_score_gemma":0.00025316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001600725,"about_ca_topic_score_gemma":0.001134439,"domain_scores_codex":[0.9999588,0.000006180464,0.000003114714,0.00001080071,0.00001404096,0.000007104037],"domain_scores_gemma":[0.9999448,0.000008033535,0.00001083885,0.000006643408,0.000009592114,0.00002008264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003540397,0.00005540531,0.001693665,0.0001447416,0.00002088546,0.001190018,0.0001458642,0.002569474,0.9865413,0.001984177,0.0005361537,0.004764206],"study_design_scores_gemma":[0.0001942131,0.0009986521,0.04869542,0.00009476744,0.0001928463,0.003777241,0.000660617,0.05477323,0.8332049,0.0043691,0.05293093,0.0001081817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890956,0.002057115,0.005193248,0.0005305521,0.0001362511,0.000009559686,0.0002819246,0.0001324013,0.002563379],"genre_scores_gemma":[0.992339,0.000995055,0.003520283,0.00008098677,0.00002657112,0.000003312146,0.001364619,0.00001663939,0.001653391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001600725,"threshold_uncertainty_score":0.003705621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0121013575084759,"score_gpt":0.2480474111912257,"score_spread":0.2359460536827498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}