{"id":"W4297239036","doi":"10.1021/acsinfecdis.1c00658","title":"Broad Tricyclic Ring Inhibitors Block SARS-CoV-2 Spike Function Required for Viral Entry","year":2022,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of General Medical Sciences; National Institutes of Health; University of Minnesota","keywords":"Viral entry; Coronavirus; Lipid bilayer fusion; Receptor; Biology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Cell biology; Chemistry; Biophysics; Virology; Coronavirus disease 2019 (COVID-19); Virus; Biochemistry; Viral replication; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009472032,0.0003345454,0.0003220485,0.000170359,0.0001002574,0.0001829169,0.0002156727,0.0001530413,0.001235281],"category_scores_gemma":[0.0001089563,0.0001061859,0.0001638811,0.0001119405,0.0001662917,0.0001291825,0.0001317759,0.0003339661,0.0002660068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002532245,"about_ca_system_score_gemma":0.0001973789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007254014,"about_ca_topic_score_gemma":0.002453116,"domain_scores_codex":[0.9999075,0.0000134706,0.000007131177,0.00001460625,0.00002773911,0.00002951416],"domain_scores_gemma":[0.999953,0.000007605146,0.00001551956,0.000004850085,0.000008098973,0.00001095381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002294843,0.00008148172,0.0001805554,0.00008778832,0.00001439889,0.00005913162,0.00001959863,0.0004834239,0.9926494,0.0002729508,0.0001855845,0.005736199],"study_design_scores_gemma":[0.0001958417,0.003278055,0.004394601,0.00001971681,0.00004374398,0.0004769212,0.00003042395,0.002475753,0.9835098,0.00009783523,0.005463688,0.0000137565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865919,0.003789399,0.002911923,0.00008893872,0.00003446413,0.00009392726,0.0005101623,0.0001112989,0.005867921],"genre_scores_gemma":[0.9937041,0.00217432,0.001878205,0.00006385436,0.00001163407,0.00003390788,0.0004149183,0.00001027077,0.001708818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001235281,"threshold_uncertainty_score":0.00413239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0290632060527961,"score_gpt":0.3251506811898033,"score_spread":0.2960874751370072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}