{"id":"W4297253276","doi":"10.1172/jci.insight.161244","title":"Interleukin-37 protects against acinar cell pyroptosis in acute pancreatitis","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"Pancreatitis Pathology and Treatment","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"Nanjing University; Yangzhou University; Shanghai Jiao Tong University; National Natural Science Foundation of China","keywords":"Pyroptosis; Acinar cell; Cholecystokinin; Pancreas; Acute pancreatitis; Medicine; Knockout mouse; Genetically modified mouse; In vivo; Interleukin; Endocrinology; Pharmacology; Chemistry; Internal medicine; Transgene; Inflammation; Cytokine; Biology; Inflammasome; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002463442,0.0005917749,0.0006596435,0.0003712307,0.0001599121,0.0002269142,0.0002149976,0.0002694902,0.0007466527],"category_scores_gemma":[0.0002255666,0.0001622603,0.0004270342,0.0002232388,0.0003844361,0.0002637639,0.0003066419,0.000825429,0.0002042173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001732469,"about_ca_system_score_gemma":0.0003304261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000282075,"about_ca_topic_score_gemma":0.0003225419,"domain_scores_codex":[0.9998618,0.00003102264,0.00001894785,0.00001825021,0.00002370689,0.00004620499],"domain_scores_gemma":[0.9998602,0.00001505316,0.00002917327,0.0000181337,0.00001353316,0.00006387457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007060784,0.0005980441,0.001752643,0.0003054161,0.00005536072,0.0002820126,0.00006543736,0.0002042356,0.9755618,0.000135043,0.0001758868,0.01380325],"study_design_scores_gemma":[0.001585364,0.01958031,0.03480679,0.00009056016,0.0004043908,0.001669668,0.0001846874,0.001887283,0.9310433,0.000522751,0.008189856,0.00003488626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883962,0.009086321,0.001492565,0.0001207614,0.0001063546,0.0000475254,0.00009776749,0.0001022395,0.0005503694],"genre_scores_gemma":[0.9944126,0.003542827,0.0009748361,0.00008231289,0.00004316292,0.00004423768,0.0002362868,0.00001252242,0.0006511532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007466527,"threshold_uncertainty_score":0.002497852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01143160211056101,"score_gpt":0.2421664894156635,"score_spread":0.2307348873051025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}