{"id":"W4297253552","doi":"10.4049/jimmunol.2100901","title":"Negative Cross-Talk between TLR2/4-Independent AMPKα1 and TLR2/4-Dependent JNK Regulates <i>S. pneumoniae</i>–Induced Mucosal Innate Immune Response","year":2022,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institutes of Health; Ministry of Education, Culture, Sports, Science and Technology; National Institute on Deafness and Other Communication Disorders; Japan Society for the Promotion of Science; Georgia Research Alliance","keywords":"TLR2; Innate immune system; AMPK; Protein kinase A; Cell biology; Mucin; Immune system; Signal transduction; Biology; Pneumolysin; Downregulation and upregulation; Kinase; Streptococcus pneumoniae; Immunology; Chemistry; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002058874,0.0005241977,0.000440182,0.0002401384,0.0003448078,0.0003497104,0.0002255275,0.0003820684,0.002890397],"category_scores_gemma":[0.00009940692,0.0002109329,0.0007564591,0.0001369889,0.000355233,0.0003227813,0.0004010922,0.0008112055,0.0006091996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003431212,"about_ca_system_score_gemma":0.0003088559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003362962,"about_ca_topic_score_gemma":0.0005392226,"domain_scores_codex":[0.9997347,0.00003645857,0.00002534251,0.00006035231,0.00004734036,0.00009583942],"domain_scores_gemma":[0.9998915,0.000005381407,0.00004451931,0.000007172203,0.00001694974,0.00003452817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001024314,0.00006301434,0.0006050516,0.0003261193,0.00002652673,0.000124518,0.00002528062,0.00007518577,0.9958417,0.0001602058,0.0001992562,0.001528928],"study_design_scores_gemma":[0.000215519,0.001018369,0.0470199,0.00008026191,0.0001323891,0.0009636781,0.0002936343,0.002704258,0.9369351,0.0003809449,0.01022105,0.0000348747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815804,0.008309825,0.004427929,0.0007179138,0.0003145433,0.00007589485,0.0009678352,0.0001312356,0.003474489],"genre_scores_gemma":[0.9919629,0.00213627,0.001806777,0.0002829927,0.00006921562,0.00009139791,0.0007175807,0.00001874365,0.002914344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002890397,"threshold_uncertainty_score":0.009669363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0235117464231717,"score_gpt":0.3299196203018093,"score_spread":0.3064078738786375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}