{"id":"W4297260847","doi":"10.3310/pnxb5040","title":"Plasma exchange and glucocorticoids to delay death or end-stage renal disease in anti-neutrophil cytoplasm antibody-associated vasculitis: PEXIVAS non-inferiority factorial RCT","year":2022,"lang":"en","type":"article","venue":"Health Technology Assessment","topic":"Vasculitis and related conditions","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; Mount Sinai Hospital; St. Michael's Hospital; Western University; McMaster University; St. Paul's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; U.S. Food and Drug Administration; Ministry of Health, Labour and Welfare; Medical Research Council; Universität Wien; National Institutes of Health; University of Birmingham; University of Southampton; University of East Anglia; National Institute for Health and Care Research; University of Oxford; Ionis Pharmaceuticals; Health Technology Assessment Programme; Bayer HealthCare; National Health and Medical Research Council; University of Cambridge; Cancer Research UK; Medizinische Universität Wien; Cambridge University Hospitals; Japan Agency for Medical Research and Development","keywords":"Medicine; Microscopic polyangiitis; Anti-neutrophil cytoplasmic antibody; Vasculitis; Rituximab; Internal medicine; Azathioprine; Autoantibody; Immunology; Prednisolone; Regimen; Gastroenterology; Antibody; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008391068,0.002346449,0.005598836,0.0007537463,0.0006361952,0.002135437,0.001134201,0.002722384,0.009311715],"category_scores_gemma":[0.008369792,0.0008159038,0.005452511,0.0007269678,0.001561669,0.001893757,0.001136565,0.002550926,0.0006971795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001539738,"about_ca_system_score_gemma":0.00189844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001024734,"about_ca_topic_score_gemma":0.001809439,"domain_scores_codex":[0.9935924,0.004554328,0.0005856905,0.000523871,0.0002625387,0.0004810647],"domain_scores_gemma":[0.9953716,0.002054825,0.001261643,0.000463106,0.0003075829,0.0005411555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9784625,0.003656947,0.0003154105,0.003511646,0.00369305,0.00004270897,0.00006797878,0.0002632985,0.0009399049,0.0003125041,0.0002579292,0.00847628],"study_design_scores_gemma":[0.9492965,0.04628964,0.0007092074,0.0002305659,0.001892752,0.0000220939,0.00003557126,0.0002950597,0.0001535249,0.000448399,0.0006107581,0.00001581633],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8879069,0.03192733,0.008175125,0.002008263,0.004428085,0.05825805,0.001601423,0.0003410939,0.00535378],"genre_scores_gemma":[0.9332001,0.005233679,0.008048462,0.001392707,0.0009570887,0.0470014,0.0003474368,0.00002538558,0.003793895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009311715,"threshold_uncertainty_score":0.04437673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02213436275654016,"score_gpt":0.3502057798034055,"score_spread":0.3280714170468653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}