{"id":"W4297260847","doi":"10.3310/pnxb5040","title":"Plasma exchange and glucocorticoids to delay death or end-stage renal disease in anti-neutrophil cytoplasm antibody-associated vasculitis: PEXIVAS non-inferiority factorial RCT","year":2022,"lang":"en","type":"article","venue":"Health Technology Assessment","topic":"Vasculitis and related conditions","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; Mount Sinai Hospital; St. Michael's Hospital; Western University; McMaster University; St. Paul's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; U.S. Food and Drug Administration; Ministry of Health, Labour and Welfare; Medical Research Council; Universität Wien; National Institutes of Health; University of Birmingham; University of Southampton; University of East Anglia; National Institute for Health and Care Research; University of Oxford; Ionis Pharmaceuticals; Health Technology Assessment Programme; Bayer HealthCare; National Health and Medical Research Council; University of Cambridge; Cancer Research UK; Medizinische Universität Wien; Cambridge University Hospitals; Japan Agency for Medical Research and Development","keywords":"Medicine; Microscopic polyangiitis; Anti-neutrophil cytoplasmic antibody; Vasculitis; Rituximab; Internal medicine; Azathioprine; Autoantibody; Immunology; Prednisolone; Regimen; Gastroenterology; Antibody; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006277041,0.000360397,0.0008837456,0.0008581558,0.0007873474,0.00002900022,0.0002096584,0.0003190507,0.0006440969],"category_scores_gemma":[0.0001319546,0.0003288173,0.0001383245,0.001108613,0.0001300981,0.00009301641,0.000432952,0.001526549,0.00001098459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001499686,"about_ca_system_score_gemma":0.001816686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007661013,"about_ca_topic_score_gemma":0.0004194293,"domain_scores_codex":[0.9966093,0.0002419071,0.000784781,0.0008091389,0.0005883944,0.0009665018],"domain_scores_gemma":[0.998377,0.00008987473,0.0002529236,0.0005919422,0.00009382727,0.0005944537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001020006,0.003819586,0.9565862,0.0007260243,0.0007951931,0.008281313,0.001086801,0.0004031306,0.003042542,0.01199062,0.001487106,0.01076149],"study_design_scores_gemma":[0.01213902,0.003368917,0.961556,0.0003125582,0.0001825903,0.0003261135,0.0006593973,0.001175794,0.00009543621,0.0003352062,0.01936704,0.0004819809],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792718,0.0004750024,0.000451292,0.01591071,0.0007329236,0.002094543,0.0006087473,0.0003400779,0.0001149573],"genre_scores_gemma":[0.9952142,0.001439206,0.0007960386,0.0007848504,0.000112354,0.0008202567,0.0005113849,0.00005037814,0.0002713082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01787994,"threshold_uncertainty_score":0.9999164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02213436275654016,"score_gpt":0.3502057798034055,"score_spread":0.3280714170468653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}