{"id":"W4297261567","doi":"10.3389/fcell.2022.954099","title":"The interplay between physical cues and mechanosensitive ion channels in cancer metastasis","year":2022,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Fonds de recherche du Québec – Nature et technologies; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Mechanosensitive channels; Metastasis; Tumor microenvironment; Mechanotransduction; Biology; Neuroscience; Intravasation; Ion channel; Cancer; Cancer cell; Cell biology; Receptor; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003423008,0.0005530092,0.0007851016,0.001311664,0.0002443374,0.00070416,0.0004921572,0.0009969595,0.002171352],"category_scores_gemma":[0.0003799019,0.0001727477,0.0003421259,0.001240309,0.0004233261,0.00110156,0.0006110741,0.001440789,0.00128791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004986435,"about_ca_system_score_gemma":0.0008572266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006537081,"about_ca_topic_score_gemma":0.001159197,"domain_scores_codex":[0.9999043,0.00001801289,0.0000127921,0.00001594267,0.00003574384,0.0000132669],"domain_scores_gemma":[0.9998739,0.00005447699,0.00001487537,0.000003801034,0.00003653145,0.00001649314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007364809,0.00005756219,0.000179254,0.01434064,0.00006265406,0.0002911272,0.0000906396,0.0005509834,0.004689421,0.010289,0.02895877,0.9404163],"study_design_scores_gemma":[0.00001199734,0.00008921274,0.0008125377,0.001968543,0.00005487528,0.001176104,0.00005435858,0.000115624,0.0007169092,0.00375738,0.991227,0.00001557388],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001405074,0.9983147,0.0001708479,0.000355249,0.0001892492,0.000002640941,0.00001082195,0.000007034031,0.0008090212],"genre_scores_gemma":[0.000841713,0.9982654,0.0001346429,0.0001556029,0.0001349031,0.000004034285,0.00001522128,9.974516e-7,0.0004474883],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002171352,"threshold_uncertainty_score":0.007263839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0386878707559198,"score_gpt":0.3329887026047097,"score_spread":0.2943008318487899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}