{"id":"W4297266462","doi":"10.1210/endocr/bqac159","title":"The Molecular Determinants of Glucagon-like Peptide Secretion by the Intestinal L cell","year":2022,"lang":"en","type":"review","venue":"Endocrinology","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Temerty Faculty of Medicine, University of Toronto; Canadian Institutes of Health Research; University of Toronto","keywords":"Secretion; Paracrine signalling; Glucagon-like peptide-1; Glucagon-like peptide-2; Endocrinology; Biology; Internal medicine; Intestinal epithelium; Hormone; Gastrointestinal hormone; Cell; Peptide hormone; Stimulation; Endogeny; Glucagon; Epithelium; Peptide; Receptor; Medicine; Biochemistry; Type 2 diabetes; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002724974,0.0006765526,0.001014923,0.001277222,0.0001879022,0.001041062,0.0005601146,0.0006511618,0.001923342],"category_scores_gemma":[0.0003595699,0.000218479,0.0003567378,0.001193784,0.0004562826,0.001083298,0.0005687401,0.001494655,0.001646015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000514042,"about_ca_system_score_gemma":0.0007998633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006133667,"about_ca_topic_score_gemma":0.0007265834,"domain_scores_codex":[0.9998986,0.0000132513,0.00001678802,0.000017113,0.00004102013,0.0000132914],"domain_scores_gemma":[0.9998956,0.0000432725,0.00001844656,0.00000289472,0.00002726366,0.00001250227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001160833,0.00005148114,0.0002367444,0.01805807,0.00006227359,0.0003190268,0.00007058131,0.0002635609,0.008661558,0.004552342,0.01495976,0.9526485],"study_design_scores_gemma":[0.00002135176,0.0001245571,0.001790764,0.003190316,0.00008167727,0.001611745,0.0001019926,0.00007213088,0.001886347,0.002591808,0.9884997,0.00002757201],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001922089,0.9980391,0.0001346753,0.0002212298,0.000185034,0.000004525206,0.0000221923,0.000007563146,0.001193505],"genre_scores_gemma":[0.0006464183,0.9985635,0.0001292584,0.0001136287,0.00009136159,0.000005789686,0.000024269,8.588907e-7,0.0004248595],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001923342,"threshold_uncertainty_score":0.006434262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03010775907578622,"score_gpt":0.3113426348219284,"score_spread":0.2812348757461421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}