{"id":"W4297311210","doi":"10.1016/j.omtm.2022.09.011","title":"The engineered AAV2-HBKO promotes non-invasive gene delivery to large brain regions beyond ultrasound targeted sites","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; Sunnybrook Health Science Centre; University of New Brunswick","funders":"","keywords":"Gene delivery; Microbubbles; Transduction (biophysics); Blood–brain barrier; Striatum; Transgene; Genetic enhancement; Reporter gene; Biodistribution; Neuroscience; Medicine; Biology; Central nervous system; Gene; Gene expression; In vivo; Ultrasound; Biophysics; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002019081,0.0006082777,0.0003352788,0.000298653,0.0001121981,0.000318887,0.0002076672,0.0003624593,0.0006782364],"category_scores_gemma":[0.0001511109,0.0002271464,0.0001701994,0.0001182183,0.0003084298,0.0003158965,0.0002610148,0.0004221934,0.0003718075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002419102,"about_ca_system_score_gemma":0.0002880814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008980685,"about_ca_topic_score_gemma":0.001229986,"domain_scores_codex":[0.9998581,0.00002278978,0.00001395848,0.0000375234,0.00004455334,0.00002304347],"domain_scores_gemma":[0.9999286,0.00001179971,0.00002115449,0.000009281352,0.00001200253,0.0000172217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001391033,0.00001149893,0.00004284743,0.00001517089,0.000002342674,0.00001953399,0.000006662031,0.00005383994,0.9986777,0.0001081624,0.00002399447,0.001024286],"study_design_scores_gemma":[0.00001603573,0.0001742215,0.001300921,0.000008402232,0.00001032654,0.0004688213,0.000007422379,0.001437677,0.9922583,0.00006430022,0.004248044,0.000005524994],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9214554,0.002832466,0.06971614,0.000266266,0.00008591807,0.0002045416,0.0004886325,0.0008463555,0.004104197],"genre_scores_gemma":[0.9436334,0.002139722,0.04232903,0.0001288559,0.00003489615,0.0001852855,0.0006483489,0.0001406732,0.01075966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008980685,"threshold_uncertainty_score":0.00226897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0422319675041012,"score_gpt":0.3895438506231325,"score_spread":0.3473118831190313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}