{"id":"W4297312817","doi":"10.1016/j.jcyt.2022.07.014","title":"Particulates are everywhere, but are they harmful in cell and gene therapies?","year":2022,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"International Society for Cellular Therapy","funders":"","keywords":"Particulates; Gene; Biology; Genetics; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00330739,0.0006427633,0.001550313,0.000829949,0.00180385,0.004589759,0.0008534628,0.004784021,0.01095247],"category_scores_gemma":[0.007389221,0.0004224502,0.0008189705,0.0007090989,0.007388623,0.00876147,0.001785133,0.00588268,0.006095825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001228112,"about_ca_system_score_gemma":0.001829937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001491016,"about_ca_topic_score_gemma":0.001492711,"domain_scores_codex":[0.9973508,0.0006562694,0.0001525441,0.0003329632,0.001249318,0.0002580239],"domain_scores_gemma":[0.9953828,0.001844711,0.0007266623,0.0004641356,0.001191373,0.0003903318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007437423,0.0003602579,0.007447857,0.005629161,0.000398234,0.002488385,0.001988515,0.0005529871,0.03544561,0.1635113,0.2319728,0.5494611],"study_design_scores_gemma":[0.00003496365,0.0003124776,0.001445954,0.001602676,0.0001190573,0.00285545,0.002700611,0.0001113215,0.0124813,0.06401047,0.9142662,0.00005956447],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.01499952,0.5270014,0.01658893,0.3860121,0.02383171,0.000060297,0.0004201923,0.0003272814,0.03075861],"genre_scores_gemma":[0.1955633,0.568173,0.009530432,0.1440902,0.02100901,0.0001728143,0.0005340018,0.0004899295,0.06043741],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.01095247,"threshold_uncertainty_score":0.03663969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03025804853908798,"score_gpt":0.2890486513950343,"score_spread":0.2587906028559463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}