{"id":"W4297317970","doi":"10.30683/1929-2279.2022.11.02","title":"The Role of 5' Adenosine Monophosphate-Activated Protein Kinase in the Chemo-Sensitivity and Metabolic Behaviour of Breast Cancer Cells Exposed to Hypoxia and Hyperglycaemia","year":2022,"lang":"en","type":"article","venue":"Journal of cancer research updates","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cancer Research UK; Saudi Arabian Cultural Bureau","keywords":"AMPK; Protein kinase A; Endocrinology; Internal medicine; Chemistry; Glucose uptake; AMP-activated protein kinase; Adenosine monophosphate; mTORC1; Glucose transporter; Cancer cell; Adenosine; Biology; Kinase; Apoptosis; Insulin; Protein kinase B; Biochemistry; Medicine; Cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001281392,0.0001758141,0.0002266091,0.0001897042,0.0001806546,0.0003937292,0.0001552762,0.0003241635,0.001419792],"category_scores_gemma":[0.0001013428,0.0001248639,0.0002611594,0.0002194678,0.0001490434,0.0001891086,0.00015579,0.0003403748,0.0003719348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003813283,"about_ca_system_score_gemma":0.0001609997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007764816,"about_ca_topic_score_gemma":0.0007709813,"domain_scores_codex":[0.9998621,0.00002071309,0.00001380655,0.00002726061,0.00003705856,0.00003900217],"domain_scores_gemma":[0.9999366,0.000009365352,0.00002051207,0.000004440304,0.00001464812,0.00001440504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008208562,0.00006174317,0.002681154,0.0002519824,0.00001936259,0.0001318376,0.00006992948,0.0001146891,0.9918098,0.00009856644,0.0002630936,0.003676893],"study_design_scores_gemma":[0.00004242745,0.0009124102,0.1809754,0.00005481103,0.00006902199,0.0009842966,0.0003385195,0.001507527,0.8072815,0.0002078315,0.007598982,0.0000273034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808519,0.0135982,0.001183383,0.0004574669,0.00008935254,0.00002602014,0.001062999,0.00003853457,0.002692164],"genre_scores_gemma":[0.9920987,0.004104355,0.0008926222,0.0001735441,0.0000210032,0.00004890212,0.0009450303,0.000007888691,0.001707859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001419792,"threshold_uncertainty_score":0.004749656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0138993025670053,"score_gpt":0.2979971982239367,"score_spread":0.2840978956569314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}