{"id":"W4297338671","doi":"10.1158/0008-5472.can-22-0834","title":"Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Uehara Memorial Foundation; National Cancer Center Japan; Takeda Science Foundation; RIKEN; Foundation for Computational Science; Japan Agency for Medical Research and Development; Naito Foundation","keywords":"Druggability; Biology; In silico; Carcinogenesis; Mutation; Cancer research; Mutant; Genetics; Computational biology; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.002095753,0.0001101573,0.0001530497,0.0003570788,0.001502079,0.0002094161,0.0006160635,0.00002704369,0.00005728935],"category_scores_gemma":[0.0003871617,0.000124136,0.00003625482,0.001585619,0.000275276,0.0005466394,0.001522877,0.00066268,0.00000596633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007258304,"about_ca_system_score_gemma":0.001317967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001104097,"about_ca_topic_score_gemma":0.00004536298,"domain_scores_codex":[0.9972174,0.0006773596,0.0001580021,0.0005742577,0.0009474503,0.000425581],"domain_scores_gemma":[0.9975622,0.001677639,0.00007529826,0.0002936904,0.0002581899,0.0001329677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00007985118,0.0002671521,0.003791015,0.00007579,0.0001330363,0.0001129973,0.01178747,0.1365409,0.5465931,0.2115126,0.0006424675,0.0884636],"study_design_scores_gemma":[0.00255638,0.0004866126,0.1014366,0.0001732842,0.00003318554,0.0002845511,0.005059648,0.6599469,0.196783,0.02726083,0.004568415,0.001410566],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8006136,0.00009747723,0.1963941,0.000956675,0.0002892799,0.0002992056,0.00007946552,0.00004963715,0.001220566],"genre_scores_gemma":[0.9842709,0.00000736642,0.01503954,0.0000536455,0.0000758012,0.0003423573,0.000004871859,0.00001114498,0.0001943457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.523406,"threshold_uncertainty_score":0.9997978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1897931860188335,"score_gpt":0.4590355024854119,"score_spread":0.2692423164665784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}