{"id":"W4297348239","doi":"10.3390/cells11192997","title":"Populations of Tau Conformers Drive Prion-like Strain Effects in Alzheimer’s Disease and Related Dementias","year":2022,"lang":"en","type":"review","venue":"Cells","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centers for Disease Control and Prevention; Canadian Dairy Commission; National Institute on Aging; National Institutes of Health; National Institute of Neurological Disorders and Stroke; Alzheimer's Association","keywords":"Phenotype; Biology; Frontotemporal lobar degeneration; Neuroscience; Disease; Prion protein; Frontotemporal dementia; Mechanism (biology); Amyloid (mycology); Strain (injury); Tau protein; Dementia; Genetics; Virology; Alzheimer's disease; Medicine; Gene; Pathology; Philosophy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002835912,0.0007058773,0.0009223739,0.001403537,0.0001891353,0.0006415675,0.0005303457,0.000746264,0.002017569],"category_scores_gemma":[0.0003361173,0.0002145006,0.0002940006,0.001073065,0.0002846335,0.0008196337,0.0004830677,0.001208019,0.00164685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003236107,"about_ca_system_score_gemma":0.0005207068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005110683,"about_ca_topic_score_gemma":0.000880832,"domain_scores_codex":[0.999921,0.0000109931,0.0000120053,0.00001445446,0.00003265151,0.000008884506],"domain_scores_gemma":[0.9999036,0.00004026305,0.00001515697,0.000002936282,0.00002690705,0.00001113728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001088793,0.00007791159,0.000157126,0.01654652,0.00007253286,0.0002502478,0.00005727281,0.0003907363,0.006141239,0.003919158,0.02284957,0.9494288],"study_design_scores_gemma":[0.00002908965,0.0001709011,0.001260387,0.003374822,0.0001353532,0.00172027,0.00004913335,0.0001321073,0.001838213,0.003120426,0.9881445,0.00002472225],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001758144,0.9986754,0.0001188074,0.00013271,0.0001000017,0.00000401949,0.00001774909,0.00000963312,0.000765743],"genre_scores_gemma":[0.0006095673,0.9987994,0.00009281393,0.00008412722,0.00006223613,0.000004919841,0.0000202455,0.000001056949,0.0003256819],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002017569,"threshold_uncertainty_score":0.006749392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03127970563795581,"score_gpt":0.3099925725217419,"score_spread":0.2787128668837861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}