{"id":"W4297348239","doi":"10.3390/cells11192997","title":"Populations of Tau Conformers Drive Prion-like Strain Effects in Alzheimer’s Disease and Related Dementias","year":2022,"lang":"en","type":"review","venue":"Cells","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centers for Disease Control and Prevention; Canadian Dairy Commission; National Institute on Aging; National Institutes of Health; National Institute of Neurological Disorders and Stroke; Alzheimer's Association","keywords":"Phenotype; Biology; Frontotemporal lobar degeneration; Neuroscience; Disease; Prion protein; Frontotemporal dementia; Mechanism (biology); Amyloid (mycology); Strain (injury); Tau protein; Dementia; Genetics; Virology; Alzheimer's disease; Medicine; Gene; Pathology; Philosophy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000147567,0.0002243571,0.0004424599,0.00009681525,0.00005929279,0.00001222957,0.0001588843,0.0001506628,0.0001853269],"category_scores_gemma":[0.00004415861,0.0002218208,0.0002429095,0.0001309888,0.00005725912,0.000003337082,0.000187999,0.0001437751,0.000003448831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001793137,"about_ca_system_score_gemma":0.000216277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000124282,"about_ca_topic_score_gemma":0.000003832255,"domain_scores_codex":[0.998799,0.0001598315,0.000397955,0.0003432624,0.0001132645,0.0001866493],"domain_scores_gemma":[0.9992684,0.0000329797,0.0002608227,0.0002825553,0.00001399593,0.0001412434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001752283,0.00006169004,0.00004094313,0.003126948,0.0003129778,0.00002140528,0.00002531398,0.00003015707,0.0004178841,0.0001333269,0.0003427746,0.995469],"study_design_scores_gemma":[0.0004721032,0.0001019704,0.0001515412,0.001260305,0.001349834,0.000004010365,0.00002390338,0.00001709107,0.0001363472,0.0001344609,0.9959719,0.0003765599],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000591398,0.9978393,0.00001747633,0.000005094696,0.0002049318,0.0009917408,0.0002418701,0.000005498257,0.000102645],"genre_scores_gemma":[0.001801011,0.9962031,0.0001051725,0.00002790902,0.00002419935,0.0001156056,0.00163211,0.00003023303,0.00006071307],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9956291,"threshold_uncertainty_score":0.9045588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03127970563795581,"score_gpt":0.3099925725217419,"score_spread":0.2787128668837861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}