{"id":"W4297348341","doi":"10.3390/cells11193016","title":"Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Mitacs; Providence Health Care","keywords":"Asthma; Inflammation; Medicine; Allergic asthma; Airway; Immunology; Allergic inflammation; Tissue remodeling; Hedgehog; Signal transduction; Biology; Cell biology; Surgery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002067282,0.0002214265,0.000436925,0.0002537503,0.0001123144,0.0003125166,0.0002165362,0.000359979,0.001143167],"category_scores_gemma":[0.00007568143,0.00008311735,0.0003661825,0.0001851307,0.0001525453,0.0001679982,0.0001979232,0.001064091,0.0002939532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001922347,"about_ca_system_score_gemma":0.0001639588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002531076,"about_ca_topic_score_gemma":0.0009623688,"domain_scores_codex":[0.9999236,0.00001840786,0.000005957968,0.000009415361,0.00002129483,0.00002129427],"domain_scores_gemma":[0.9999765,0.000003780467,0.00000644951,0.00000239267,0.000004234281,0.000006577581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004576155,0.001527951,0.002624137,0.002790939,0.0003217394,0.0009700666,0.000112931,0.0007173802,0.5567924,0.003075078,0.007474097,0.4190171],"study_design_scores_gemma":[0.006247375,0.03338465,0.07538677,0.001051728,0.002075698,0.005768933,0.0004197973,0.00468814,0.4132949,0.004393082,0.4531896,0.00009938278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4293383,0.5466073,0.004193322,0.004309631,0.001002643,0.0003553368,0.0006539864,0.0004093007,0.01313016],"genre_scores_gemma":[0.8149884,0.1719913,0.004100606,0.001663953,0.0004623061,0.0001864911,0.0007938758,0.00002846926,0.005784657],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001143167,"threshold_uncertainty_score":0.003824234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01440027644299216,"score_gpt":0.2444712908914028,"score_spread":0.2300710144484107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}