{"id":"W4297348341","doi":"10.3390/cells11193016","title":"Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Mitacs; Providence Health Care","keywords":"Asthma; Inflammation; Medicine; Allergic asthma; Airway; Immunology; Allergic inflammation; Tissue remodeling; Hedgehog; Signal transduction; Biology; Cell biology; Surgery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004301893,0.0001254469,0.0001358582,0.0000609398,0.0001832485,0.00001711777,0.000107293,0.0000573226,0.00002220343],"category_scores_gemma":[0.00003455473,0.0001359544,0.00005377322,0.00007709825,0.0000294123,0.000003137771,0.0001334698,0.00009252199,0.000003126258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002487254,"about_ca_system_score_gemma":0.00005460247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008085643,"about_ca_topic_score_gemma":0.000006222082,"domain_scores_codex":[0.9990848,0.00007685684,0.0002078409,0.0003103832,0.0001017546,0.0002184091],"domain_scores_gemma":[0.9996796,0.00003182984,0.0000648667,0.0001460372,0.00004187775,0.00003577965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000786816,0.00001897362,0.0001032562,0.00002799785,0.0000223416,0.000002189643,0.000522217,0.02730884,0.9681118,0.00005066594,0.00008369383,0.003669386],"study_design_scores_gemma":[0.0008894392,0.0004759144,0.00004398834,0.00001413722,0.000009095895,0.000007219377,0.0007811044,0.008571315,0.9168339,0.001044717,0.0710705,0.0002586366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906859,0.003050232,0.005301474,0.0001686194,0.0001361494,0.0003493726,0.00001252625,0.00001349313,0.0002822569],"genre_scores_gemma":[0.9975656,0.00008503585,0.001371133,0.0002164809,0.0001397511,0.0001241117,0.00005906287,0.00002641999,0.000412466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07098681,"threshold_uncertainty_score":0.5544057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01440027644299216,"score_gpt":0.2444712908914028,"score_spread":0.2300710144484107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}