{"id":"W4297349363","doi":"10.1155/2022/6889278","title":"Ischemic Preconditioning and Postconditioning Protect the Heart by Preserving the Mitochondrial Network","year":2022,"lang":"en","type":"article","venue":"BioMed Research International","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Medical Research Council; Duke-NUS Medical School; Medical Research Council; Chinese University of Hong Kong; Ministry of Health, British Columbia; Aromatic Plant Research Center","keywords":"MFN2; Downregulation and upregulation; MFN1; Mitochondrial fission; mitochondrial fusion; Mitochondrion; Cell biology; Ischemic preconditioning; Cardioprotection; Mitochondrial permeability transition pore; Ischemia; Chemistry; Apoptosis; Biology; Programmed cell death; Medicine; Gene; Biochemistry; Mitochondrial DNA; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017087,0.0005446546,0.0002861013,0.0001903547,0.0001629202,0.0002106246,0.000203124,0.0003158148,0.001643223],"category_scores_gemma":[0.0001020048,0.00007910401,0.0003618996,0.0001216888,0.000271675,0.0003059673,0.0001916068,0.0006105356,0.0001580319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002518203,"about_ca_system_score_gemma":0.0003053804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001910369,"about_ca_topic_score_gemma":0.0003040046,"domain_scores_codex":[0.9999034,0.000008534297,0.00001029489,0.00002509152,0.00002539673,0.00002732009],"domain_scores_gemma":[0.9998955,0.000005993601,0.00004287834,0.00001219086,0.00001024134,0.00003316406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004439999,0.0000978904,0.0003481834,0.0001310223,0.00001515616,0.00006586877,0.00001371738,0.00009165631,0.9942126,0.0001897257,0.00007523477,0.004314975],"study_design_scores_gemma":[0.00009997519,0.002212381,0.02197589,0.00003545593,0.00008513371,0.0005374447,0.00002367532,0.0008174723,0.9712087,0.0002548521,0.002740134,0.000008856132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843668,0.004689011,0.007604688,0.0002469558,0.0001408848,0.00008541916,0.0004310936,0.0001781302,0.002256937],"genre_scores_gemma":[0.9928382,0.001617405,0.003420277,0.0001276552,0.00007538096,0.0001202807,0.0006867904,0.00001577412,0.001098168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001643223,"threshold_uncertainty_score":0.005497098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02628828237856781,"score_gpt":0.3362773846797763,"score_spread":0.3099891023012085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}