{"id":"W4297364309","doi":"10.1016/j.ebiom.2022.104271","title":"Baseline host determinants of robust human HIV-1 vaccine-induced immune responses: A meta-analysis of 26 vaccine regimens","year":2022,"lang":"en","type":"review","venue":"EBioMedicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"Janssen Pharmaceuticals; National Cancer Institute; Center for AIDS Research, Duke University; National Institute of Dental and Craniofacial Research; Centers for Disease Control and Prevention; James B. Pendleton Charitable Trust; Patient-Centered Outcomes Research Institute; National Institute of General Medical Sciences; National Institute of Mental Health; Battelle; Paul G. Allen Family Foundation; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Medicine; HIV vaccine; Immunology; Antibody; Immune system; Vaccination; Meta-analysis; Vaccine trial; Clinical trial; Vaccine efficacy; Viral load; Internal medicine; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002856506,0.0008915929,0.01085987,0.003492534,0.0002573826,0.00000648032,0.001020139,0.0005180646,0.02566417],"category_scores_gemma":[0.0006163627,0.0005835124,0.003737173,0.003241503,0.0001743371,0.00005169682,0.0005154213,0.0009002755,0.0002834111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001950079,"about_ca_system_score_gemma":0.0004588535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007490485,"about_ca_topic_score_gemma":0.0001911268,"domain_scores_codex":[0.9926037,0.002467582,0.002861471,0.0009754275,0.0003118092,0.0007799983],"domain_scores_gemma":[0.9937173,0.001840833,0.002010878,0.002088588,0.000223867,0.0001185397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001203723,0.002867585,0.0001685297,0.0095631,0.8353271,0.0009096896,0.000496177,0.00000190067,0.01013433,0.00003146224,0.01176094,0.1275354],"study_design_scores_gemma":[0.00235265,0.001690236,0.0001704856,0.0005153024,0.3642494,0.0001243103,0.0001040503,0.000001287094,0.0005635881,0.000001249761,0.6298673,0.0003600923],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001012086,0.9931288,0.00001351084,0.0001702297,0.0002185519,0.001375741,0.003882655,0.00006029668,0.0001380883],"genre_scores_gemma":[0.003820339,0.9748623,0.00006887312,0.0000291331,0.00005605163,0.0004516193,0.009607619,0.0001223086,0.01098181],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6181064,"threshold_uncertainty_score":0.9996616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1557403963773575,"score_gpt":0.3939173738354338,"score_spread":0.2381769774580763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}