{"id":"W4297373452","doi":"10.1016/j.celrep.2022.111412","title":"A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre","funders":"Janssen Pharmaceuticals; Institute of Population and Public Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Weill Cornell Medical College; National Institutes of Health; Feldstein Medical Foundation; Emerson Collective; Swim Across America; Canadian Institutes of Health Research; Compute Canada; University of California, Los Angeles; Ludwig Institute for Cancer Research; National Cancer Institute; Melanoma Research Alliance; American Skin Association; Breast Cancer Research Foundation; Pfizer; Parker Institute for Cancer Immunotherapy; Eli Lilly and Company; Array BioPharma","keywords":"Lipid microdomain; Cell biology; Hippo signaling pathway; Chemistry; Signal transduction; Biology; Cancer research; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003113642,0.0001617651,0.000143471,0.00004098519,0.0002792494,0.00002947154,0.0001341863,0.00006652487,0.0002570426],"category_scores_gemma":[0.0000877467,0.0001731501,0.0000942132,0.0001041894,0.00004151113,0.000004391915,0.0001740122,0.0001585864,0.000009934398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004097685,"about_ca_system_score_gemma":0.0001240827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005800233,"about_ca_topic_score_gemma":0.000001582155,"domain_scores_codex":[0.9986472,0.0001103349,0.0002842115,0.0004852229,0.0002125712,0.0002604476],"domain_scores_gemma":[0.9992066,0.00001206835,0.0002267257,0.0004002538,0.00006261266,0.00009175055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003652033,0.0001382521,0.0006098204,0.00002094293,0.0000134678,0.0002469275,0.0001267635,0.00002084181,0.9847196,0.00001033852,0.01390294,0.0001535919],"study_design_scores_gemma":[0.0001388372,0.000167643,0.00003439513,0.000003102831,0.000007217217,0.0002440817,0.0001745874,0.000004805477,0.7060467,0.0000867068,0.2929251,0.0001668151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949124,0.0006141002,0.00009313215,0.00006342623,0.0002800289,0.0001684513,0.00004656864,0.00003899755,0.003782937],"genre_scores_gemma":[0.9964129,0.00001995744,0.0001529139,0.0003832064,0.0001173615,0.00004587928,0.0005298851,0.00004833111,0.002289546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2790222,"threshold_uncertainty_score":0.7060856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004288957890251657,"score_gpt":0.1840560589577088,"score_spread":0.1797671010674571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}