{"id":"W4297373452","doi":"10.1016/j.celrep.2022.111412","title":"A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre","funders":"Janssen Pharmaceuticals; Institute of Population and Public Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Weill Cornell Medical College; National Institutes of Health; Feldstein Medical Foundation; Emerson Collective; Swim Across America; Canadian Institutes of Health Research; Compute Canada; University of California, Los Angeles; Ludwig Institute for Cancer Research; National Cancer Institute; Melanoma Research Alliance; American Skin Association; Breast Cancer Research Foundation; Pfizer; Parker Institute for Cancer Immunotherapy; Eli Lilly and Company; Array BioPharma","keywords":"Lipid microdomain; Cell biology; Hippo signaling pathway; Chemistry; Signal transduction; Biology; Cancer research; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009571583,0.0001978557,0.000242291,0.0001803589,0.0001660388,0.0002350482,0.0002263964,0.0001997792,0.00092347],"category_scores_gemma":[0.00012283,0.00009527917,0.0001446752,0.00009350297,0.0004042739,0.000151535,0.0002248347,0.0006420956,0.0001424695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002146596,"about_ca_system_score_gemma":0.0003229161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005064525,"about_ca_topic_score_gemma":0.001115627,"domain_scores_codex":[0.9999125,0.00001660074,0.000006754021,0.00001503928,0.00002425795,0.00002475894],"domain_scores_gemma":[0.9999149,0.00001829541,0.00002222118,0.00001223038,0.000006619854,0.00002573917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001493819,0.00005699612,0.00006918183,0.00001899299,0.000002933213,0.00002558627,0.00001213795,0.00008567096,0.9981824,0.0002280558,0.00004803987,0.00112062],"study_design_scores_gemma":[0.00003599369,0.0004419426,0.0008251321,0.000004680075,0.000007757236,0.000107896,0.00002857754,0.0009998854,0.9959394,0.0000695336,0.001535781,0.000003548563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995522,0.0007119068,0.001700688,0.0002084777,0.00003054053,0.00002088115,0.0001033689,0.0001030573,0.00159902],"genre_scores_gemma":[0.9976973,0.0003069363,0.000804877,0.00003152744,0.000007815313,0.00002216666,0.0001288216,0.00001739627,0.0009830741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00092347,"threshold_uncertainty_score":0.003089368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004288957890251657,"score_gpt":0.1840560589577088,"score_spread":0.1797671010674571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}