{"id":"W4297394691","doi":"10.3389/fmed.2022.921967","title":"Challenges in severe asthma: Do we need new drugs or new biomarkers?","year":2022,"lang":"en","type":"review","venue":"Frontiers in Medicine","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Asthma; Intensive care medicine; Disease; Biomarker; Small airways; Clinical trial; Omalizumab; Inhaled corticosteroids; Biologic Agents; Immunology; Internal medicine; Immunoglobulin E; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001960384,0.0007841521,0.002311647,0.001548458,0.0003845318,0.001861374,0.001153263,0.002195269,0.00411268],"category_scores_gemma":[0.002830739,0.0003080853,0.0009836198,0.001525089,0.001037294,0.003947185,0.001012109,0.004432818,0.002600965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007311287,"about_ca_system_score_gemma":0.001909657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001188521,"about_ca_topic_score_gemma":0.00229227,"domain_scores_codex":[0.9993572,0.0002010382,0.00008855712,0.00007747335,0.0002184504,0.00005734048],"domain_scores_gemma":[0.9983962,0.0009236684,0.0001449682,0.00003796393,0.0004006783,0.0000964638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001218,0.00007489046,0.0002569304,0.0235469,0.0001477273,0.0002100209,0.0001466547,0.0002098609,0.0008932439,0.008745243,0.06000925,0.9056374],"study_design_scores_gemma":[0.00002710679,0.0001182237,0.0005710874,0.0136057,0.0001490734,0.0007299667,0.0002274325,0.00007957112,0.000172442,0.006642022,0.9776493,0.00002822759],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005110051,0.9960651,0.0001165796,0.002853073,0.0004370767,0.000003562486,0.00001555134,0.000006586478,0.0004514949],"genre_scores_gemma":[0.0004958059,0.9967547,0.0002703567,0.001612278,0.0005034822,0.000007031933,0.00002258151,0.000002473021,0.0003312634],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00411268,"threshold_uncertainty_score":0.0137583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07115740195567312,"score_gpt":0.3382642617154771,"score_spread":0.267106859759804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}