{"id":"W4297399657","doi":"10.1101/2022.09.23.509206","title":"A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"","keywords":"Virology; Epitope; CD8; Biology; T cell; Peptide vaccine; Antibody; Cytotoxic T cell; Immunology; Neutralizing antibody; Immune system; Immunity; Virus; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001132496,0.00051312,0.0003264915,0.0002239523,0.0001096987,0.0002015217,0.0001603352,0.0003974575,0.001243197],"category_scores_gemma":[0.00009643326,0.0001348345,0.0002201418,0.00007246431,0.000215449,0.0002125908,0.0001175982,0.0009651497,0.0003234316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001558242,"about_ca_system_score_gemma":0.0001773091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002907049,"about_ca_topic_score_gemma":0.0003916753,"domain_scores_codex":[0.999856,0.00001503508,0.000009196949,0.00003579507,0.00002819462,0.0000557733],"domain_scores_gemma":[0.9998924,0.00001611555,0.00003230751,0.000009521399,0.00001026795,0.00003944414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005278696,0.0002285349,0.0001849909,0.00002501134,0.000004635086,0.00004583775,0.00001076783,0.00007325467,0.9968452,0.00003436496,0.00006345301,0.001956167],"study_design_scores_gemma":[0.0003003436,0.0154187,0.007785782,0.00002049046,0.00005057483,0.0006250351,0.00005362761,0.001666,0.9719249,0.0001110446,0.002031845,0.0000115946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975525,0.0003136162,0.001025287,0.00008773187,0.00005128694,0.00002614636,0.0001369608,0.0000981858,0.0007082915],"genre_scores_gemma":[0.9947936,0.000404148,0.0009713206,0.0001107744,0.00004807287,0.00005031838,0.000457273,0.00002094679,0.003143549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001243197,"threshold_uncertainty_score":0.004158914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02826524280626797,"score_gpt":0.2814848840347328,"score_spread":0.2532196412284649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}