{"id":"W4297456973","doi":"10.1007/978-1-0716-2643-6_7","title":"Conventional Receptor Radioligand Binding Techniques Applied to the Study of Monoamine Oxidase","year":2022,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Radioligand; Radioligand Assay; Chemistry; Monoamine oxidase; Ligand (biochemistry); Allosteric regulation; Ligand binding assay; Biophysics; Binding site; Monoamine oxidase A; Cofactor; Membrane; Receptor; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008403423,0.001044657,0.0009193934,0.0007435157,0.0007591727,0.0007005889,0.001764756,0.001122183,0.004344248],"category_scores_gemma":[0.0008913909,0.0006850104,0.0005817669,0.0007436529,0.0008632882,0.0009085984,0.0007326999,0.003124633,0.003698714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007962514,"about_ca_system_score_gemma":0.001099411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002344009,"about_ca_topic_score_gemma":0.002920732,"domain_scores_codex":[0.9994332,0.0001138145,0.00003131078,0.0001621194,0.0001710522,0.00008841373],"domain_scores_gemma":[0.9993389,0.0002940547,0.00006064927,0.0001498355,0.00008128488,0.00007530897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001091507,0.00002974865,0.0000473443,0.0002263881,0.00001147069,0.00007254577,0.00004610947,0.00003853501,0.9923515,0.001413909,0.0001977924,0.005455484],"study_design_scores_gemma":[0.00008950674,0.0003924028,0.001595881,0.0000429805,0.00004884181,0.001062645,0.00004817446,0.001093969,0.9720064,0.001060014,0.02252599,0.00003318752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.109294,0.02111664,0.8523651,0.0008905221,0.001025756,0.0006826692,0.001054318,0.001198287,0.01237268],"genre_scores_gemma":[0.3447927,0.05486162,0.5597367,0.0008202639,0.0004679217,0.001711018,0.002888242,0.0006922396,0.03402934],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.004344248,"threshold_uncertainty_score":0.01453298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01635951551239256,"score_gpt":0.3590407177718289,"score_spread":0.3426812022594363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}