{"id":"W4297464316","doi":"10.1101/2022.09.28.509882","title":"A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Aspergillus fumigatus; Caspofungin; Microbiology; Cryptococcus neoformans; Biology; Echinocandins; Candida albicans; Amphotericin B; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001267303,0.0003568606,0.0001933896,0.0002690879,0.00009844501,0.0001478006,0.000143183,0.0001942752,0.001551514],"category_scores_gemma":[0.000107755,0.00008691878,0.000175284,0.0001280299,0.00008969858,0.0001022803,0.0001264444,0.0003215138,0.0003164155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000123821,"about_ca_system_score_gemma":0.0001148516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003184874,"about_ca_topic_score_gemma":0.0004483678,"domain_scores_codex":[0.9999294,0.00001601141,0.000007001743,0.00001179994,0.00001773873,0.00001790403],"domain_scores_gemma":[0.999954,0.00001071738,0.00001017057,0.000003992422,0.000008740282,0.00001241373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002528021,0.0001405897,0.0001680122,0.00006920208,0.00000745238,0.00005063184,0.000008275792,0.0001093086,0.9948542,0.000019807,0.0001073511,0.004212296],"study_design_scores_gemma":[0.0001537806,0.004633612,0.00628578,0.00002169639,0.00005567774,0.0005991947,0.00002334495,0.000752704,0.9828509,0.00002851304,0.004583472,0.0000113142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925391,0.004098056,0.0006854687,0.00011026,0.00004161864,0.00007174807,0.0003805507,0.00006480724,0.002008368],"genre_scores_gemma":[0.995114,0.001585525,0.001509921,0.00009316598,0.000018623,0.00002731992,0.0005256892,0.000006576557,0.001119161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001551514,"threshold_uncertainty_score":0.005190313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01829192045036385,"score_gpt":0.2498118756103188,"score_spread":0.2315199551599549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}