{"id":"W4297475217","doi":"10.1002/pro.4440","title":"A genetically encoded far‐red fluorescent calcium ion biosensor derived from a biliverdin‐binding protein","year":2022,"lang":"en","type":"article","venue":"Protein Science","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of California, San Diego; National Institutes of Health; Toyota Physical and Chemical Research Institute; Hitachi Global Foundation; Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering; National Institute of Diabetes and Digestive and Kidney Diseases; University of Tokyo; Astellas Foundation for Research on Metabolic Disorders; Astellas Pharma; University of Alberta; Montana State University; National Institute of Neurological Disorders and Stroke; Kato Memorial Bioscience Foundation; Japan Agency for Medical Research and Development; Takeda Science Foundation","keywords":"Biliverdin; Fluorescence; Green fluorescent protein; Biophysics; Far-red; Fluorescent protein; Calcium imaging; Protein engineering; In vivo; Chemistry; Calcium; Biochemistry; Biology; Optics; Heme; Genetics; Gene; Physics; Red light; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001165049,0.0002955087,0.00026802,0.0004609077,0.001895888,0.0003483617,0.002288485,0.00006402726,0.001004182],"category_scores_gemma":[0.001643134,0.0002817881,0.0001166629,0.002429779,0.001284739,0.0002585492,0.001945593,0.0005777227,0.0001646317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005342881,"about_ca_system_score_gemma":0.0007307543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001992443,"about_ca_topic_score_gemma":0.00000937523,"domain_scores_codex":[0.9934095,0.0005591724,0.0004268457,0.001589983,0.00279152,0.001223001],"domain_scores_gemma":[0.9982613,0.0001304187,0.0001544097,0.0007993879,0.0001519616,0.0005025445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001323599,0.0001753734,0.000138735,0.00001008742,0.000002391022,0.00004009008,0.0004710916,0.00006911621,0.9963333,0.0002273061,0.00001444497,0.002385732],"study_design_scores_gemma":[0.0005553665,0.0003419161,0.0004593666,0.00002318787,0.00000407184,0.000009912873,0.0001381903,0.008842331,0.9876493,0.000459452,0.001148953,0.0003679533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945543,0.00005006315,0.0006025169,0.0004438413,0.0003144298,0.002854427,0.0001435937,0.00014096,0.00089584],"genre_scores_gemma":[0.9934006,0.00000897731,0.00480235,0.0001478553,0.00007480865,0.001094071,0.000004930384,0.00003551056,0.0004308367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008773215,"threshold_uncertainty_score":0.9999634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06405867834462771,"score_gpt":0.3141888406935224,"score_spread":0.2501301623488947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}