{"id":"W4297496665","doi":"10.1016/j.devcel.2022.09.004","title":"ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains","year":2022,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Medical Research Council; Institut Curie; Dalhousie University; École Polytechnique Fédérale de Lausanne; Yale School of Medicine; National Science Foundation; Yale University; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Endoplasmic reticulum; Golgi apparatus; Biology; Cell biology; Lipid raft; Membrane contact site; Cell membrane; Membrane protein; Cell; Membrane; Golgi membrane; Biochemistry; Integral membrane protein; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001708395,0.0003049899,0.0002174159,0.0001889727,0.0002239199,0.0006566068,0.0002476245,0.0003446309,0.001018126],"category_scores_gemma":[0.0001884604,0.000225866,0.0002081151,0.0001262812,0.0002893669,0.0005196039,0.000576922,0.0006367554,0.0007023679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007783589,"about_ca_system_score_gemma":0.0002117797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006054337,"about_ca_topic_score_gemma":0.001380731,"domain_scores_codex":[0.9998584,0.00001548356,0.000009166691,0.00003124831,0.00003636786,0.00004932556],"domain_scores_gemma":[0.9998143,0.00003469517,0.00003905193,0.00001721,0.00003910593,0.00005556859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001190851,0.000008319659,0.000244908,0.00001302779,0.000001477572,0.00003885698,0.00001356501,0.00005044812,0.9986855,0.0002194598,0.00004582276,0.0005596201],"study_design_scores_gemma":[0.0000116883,0.00002209091,0.004386725,0.000003451499,0.00000289404,0.0001029571,0.00009012974,0.002085296,0.99145,0.0001258738,0.001713825,0.000005131675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889309,0.001230618,0.007052793,0.0001771109,0.00005764653,0.00001629121,0.000320102,0.000100642,0.002113921],"genre_scores_gemma":[0.9919164,0.0004244765,0.002854374,0.00005827388,0.000007575616,0.00001621144,0.0004934508,0.0000573904,0.004171917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001018126,"threshold_uncertainty_score":0.005647421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00786267020516483,"score_gpt":0.2051502919959084,"score_spread":0.1972876217907436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}