{"id":"W4297497806","doi":"10.1038/s41593-022-01164-9","title":"Developmental dynamics of RNA translation in the human brain","year":2022,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Mental Health Research Canada; Hospital for Sick Children; University of Toronto","funders":"CIHR Skin Research Training Centre; National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute; National Institute of Mental Health; Damon Runyon Cancer Research Foundation; Canadian Institutes of Health Research; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Broad Institute; Boston Children's Hospital; Paul G. Allen Family Foundation; U.S. Department of Health and Human Services; National Institutes of Health; Government of Canada; Manton Center for Orphan Disease Research, Boston Children's Hospital; Howard Hughes Medical Institute","keywords":"Ribosome profiling; Biology; Translational regulation; ORFS; Human brain; Translation (biology); Neuroscience; Open reading frame; RNA-binding protein; Transcriptome; RNA; Computational biology; Gene; Gene expression; Genetics; Messenger RNA; Peptide sequence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003636298,0.00004903681,0.00004170652,0.00003110954,0.0001371939,0.000007755708,0.0003559865,0.00004854729,0.000008566592],"category_scores_gemma":[0.00006570773,0.00003974805,0.00002488328,0.0001894087,0.00004096807,0.000002555214,0.00005093957,0.0001637939,1.302687e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009684406,"about_ca_system_score_gemma":0.00003380444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003861492,"about_ca_topic_score_gemma":0.00002655935,"domain_scores_codex":[0.9993336,0.0001101865,0.00008930401,0.0001685095,0.0002066028,0.00009177158],"domain_scores_gemma":[0.9998357,0.00001712967,0.00003884411,0.00009071634,0.000007427742,0.000010153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006985524,0.00002323603,0.0002002827,0.000001917274,2.886e-7,0.000001821826,0.00008461702,0.000040773,0.9961666,0.0009178592,0.00008474888,0.002470801],"study_design_scores_gemma":[0.000344923,0.0003744278,0.0140106,0.000004496534,0.0000029046,0.00005610533,0.0004854436,0.0004250737,0.9583459,0.001148137,0.02462352,0.0001784556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970778,0.0001141436,0.0004732211,0.0009192283,0.0001127681,0.0001429401,0.00001409445,0.000002573272,0.001143182],"genre_scores_gemma":[0.9982067,0.000004250053,0.0002479329,0.001409833,0.00001288554,0.00001735383,0.00001247936,0.000003997859,0.00008456749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03782075,"threshold_uncertainty_score":0.1620879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0128894790495294,"score_gpt":0.2619739409587525,"score_spread":0.2490844619092231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}