{"id":"W4297498192","doi":"10.1038/s42003-022-04005-4","title":"Assessing the fitness of a dual-antiviral drug resistant human influenza virus in the ferret model","year":2022,"lang":"en","type":"article","venue":"Communications Biology","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; Department of Health and Aged Care, Australian Government; Australian Government; F. Hoffmann-La Roche; Roche","keywords":"Virus; Virology; Neuraminidase; Transmission (telecommunications); Biology; Pandemic; Influenza A virus; Drug resistance; Neuraminidase inhibitor; Microbiology; H5N1 genetic structure; Medicine; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Internal medicine; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002082153,0.0001069735,0.0002645151,0.0001644827,0.001212964,0.00002051511,0.001256372,0.00003839506,0.0000228797],"category_scores_gemma":[0.0004109411,0.00006427823,0.00007664436,0.0005287212,0.001071599,0.00006372169,0.002277265,0.0008307389,0.000003552176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001095806,"about_ca_system_score_gemma":0.000186337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005997451,"about_ca_topic_score_gemma":0.0005437736,"domain_scores_codex":[0.9973429,0.00162945,0.0004203678,0.0001539761,0.0002032918,0.0002500147],"domain_scores_gemma":[0.9967191,0.0008156478,0.0001528719,0.002171619,0.0001237353,0.00001700436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008040707,0.003256254,0.1344022,0.0002087898,0.0006710545,0.00003154163,0.07262492,0.00166647,0.4109727,0.3540199,0.01189774,0.009444346],"study_design_scores_gemma":[0.01016323,0.00154812,0.4309592,0.0003419775,0.0005467601,0.0001170547,0.1072752,0.06456909,0.004926773,0.08041421,0.2979102,0.001228181],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9708713,0.004810726,0.00002152823,0.009184494,0.00002898702,0.000659855,0.00007927838,0.00002649874,0.01431739],"genre_scores_gemma":[0.9971836,0.0001787923,0.0003976048,0.001633959,0.00001325427,0.0004298027,0.00005558331,0.00001091728,0.00009652098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.406046,"threshold_uncertainty_score":0.9329261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2864058228173621,"score_gpt":0.5026285278566325,"score_spread":0.2162227050392704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}