{"id":"W4297500202","doi":"10.1523/eneuro.0253-22.2022","title":"Prenatal THC Exposure Induces Sex-Dependent Neuropsychiatric Endophenotypes in Offspring and Long-Term Disruptions in Fatty-Acid Signaling Pathways Directly in the Mesolimbic Circuitry","year":2022,"lang":"en","type":"article","venue":"eNeuro","topic":"Birth, Development, and Health","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"St Joseph's Health Care; Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Schulich School of Medicine and Dentistry; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Mitacs; Government of Canada","keywords":"Endophenotype; Offspring; Prenatal exposure; Mesolimbic pathway; Neuroscience; Term (time); Psychology; Biology; Pregnancy; Genetics; Ventral tegmental area; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008398378,0.0003194063,0.0002254155,0.0006389371,0.0002393653,0.0002321685,0.0001722613,0.0002502505,0.002118976],"category_scores_gemma":[0.0001444139,0.000212956,0.0001998583,0.0001565469,0.0004012597,0.000119396,0.0003124281,0.0006127055,0.0001994406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003390864,"about_ca_system_score_gemma":0.0003066559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002815985,"about_ca_topic_score_gemma":0.007275265,"domain_scores_codex":[0.9997892,0.00001535119,0.00001468524,0.0000702336,0.00006331392,0.00004730033],"domain_scores_gemma":[0.9997482,0.00002368982,0.0001020401,0.00002698747,0.00002969482,0.0000694243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000354337,0.00006475492,0.005300761,0.00003254108,0.00002129386,0.0003521579,0.00008966227,0.00002355539,0.9912651,0.00007334238,0.00005613063,0.002366294],"study_design_scores_gemma":[0.00002564034,0.001370782,0.3287841,0.00003611115,0.00008375429,0.001668394,0.0005066372,0.0003510946,0.6652534,0.0001743091,0.001720423,0.00002531056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971559,0.0004461402,0.0007321421,0.00007116605,0.00001799783,0.00001715195,0.0008803272,0.00003805638,0.0006412186],"genre_scores_gemma":[0.993552,0.0006718096,0.0009421541,0.00007237369,0.000005776049,0.00006361763,0.0005850568,0.00002611378,0.004081103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002815985,"threshold_uncertainty_score":0.007088661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02708621096347951,"score_gpt":0.2639812833992756,"score_spread":0.2368950724357961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}