{"id":"W4297500202","doi":"10.1523/eneuro.0253-22.2022","title":"Prenatal THC Exposure Induces Sex-Dependent Neuropsychiatric Endophenotypes in Offspring and Long-Term Disruptions in Fatty-Acid Signaling Pathways Directly in the Mesolimbic Circuitry","year":2022,"lang":"en","type":"article","venue":"eNeuro","topic":"Birth, Development, and Health","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"St Joseph's Health Care; Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Schulich School of Medicine and Dentistry; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Mitacs; Government of Canada","keywords":"Endophenotype; Offspring; Prenatal exposure; Mesolimbic pathway; Neuroscience; Term (time); Psychology; Biology; Pregnancy; Genetics; Ventral tegmental area; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005992621,0.000185705,0.0002829584,0.0004012975,0.0001881891,0.00003379025,0.0001962988,0.00005361061,0.0000394079],"category_scores_gemma":[0.00006250151,0.0001605397,0.00003905886,0.0005481645,0.00003071096,0.00008699533,0.0001421652,0.0009283616,0.000002486693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008860104,"about_ca_system_score_gemma":0.00019262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001168701,"about_ca_topic_score_gemma":0.0004521023,"domain_scores_codex":[0.9979774,0.0003719174,0.000432861,0.0004342831,0.000384497,0.0003990572],"domain_scores_gemma":[0.9994061,0.0001505268,0.00009537275,0.0002518205,0.00001110373,0.00008506732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008133207,0.0004259198,0.9524909,0.0002788809,0.00001091559,0.0009656035,0.009413661,0.00008746052,0.03074135,0.001154955,0.00000315023,0.004345905],"study_design_scores_gemma":[0.001448645,0.000211005,0.9931188,0.00007829144,0.00001561501,0.0002293112,0.001084231,0.00002746551,0.003076437,0.000539418,0.00001019626,0.0001605588],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995923,0.001979306,0.00001082511,0.0004411454,0.0003054352,0.0005466846,0.00001610843,0.00004092295,0.0007365365],"genre_scores_gemma":[0.996557,0.002124593,0.00004367167,0.0009756057,0.00009863492,0.0001413965,0.00001719029,0.00003039793,0.00001151359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04062796,"threshold_uncertainty_score":0.654662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02708621096347951,"score_gpt":0.2639812833992756,"score_spread":0.2368950724357961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}