{"id":"W4297516136","doi":"10.1101/2022.09.28.509312","title":"eIF4E phosphorylation recruits β-catenin to mRNA cap and selectively promotes Wnt pathway translation in dentate gyrus LTP maintenance in vivo","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universitetet i Bergen; Hellenic Foundation for Research and Innovation; Norges Forskningsråd; EU Joint Programme – Neurodegenerative Disease Research; McGill University","keywords":"EIF4E; Long-term potentiation; Dentate gyrus; Wnt signaling pathway; Cell biology; Phosphorylation; Synaptic plasticity; Biology; Eukaryotic initiation factor; Translation (biology); Signal transduction; Messenger RNA; Neuroscience; Biochemistry; Hippocampus; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001053856,0.0002931137,0.0002008766,0.0002456253,0.0001599415,0.0002313419,0.0001145409,0.0001572402,0.001654343],"category_scores_gemma":[0.0001068192,0.0001995982,0.000248262,0.0001223856,0.0001976984,0.0001735124,0.0002008427,0.0004432611,0.0004347447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003532438,"about_ca_system_score_gemma":0.0001729119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000493359,"about_ca_topic_score_gemma":0.0009347805,"domain_scores_codex":[0.9998999,0.000007586647,0.00001265518,0.00002897468,0.00002841597,0.00002258919],"domain_scores_gemma":[0.9999331,0.000005608396,0.00002439428,0.000007401402,0.000006960869,0.00002255767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007072929,0.000007496297,0.0001455829,0.00001738048,0.000002472116,0.00001888358,0.000003769918,0.0000176683,0.9992282,0.00003527247,0.00002399952,0.0004285432],"study_design_scores_gemma":[0.00001467533,0.00008845932,0.0100387,0.00000712311,0.00001106881,0.0001537743,0.00001583578,0.000599867,0.9875179,0.00005154643,0.001497993,0.000003027518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942185,0.0009803968,0.002703523,0.00009266338,0.00003138164,0.00002067162,0.0005825673,0.0001103362,0.001259983],"genre_scores_gemma":[0.9928033,0.000723097,0.001837337,0.00005512665,0.000009013194,0.00003737619,0.00080021,0.00003548574,0.00369907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001654343,"threshold_uncertainty_score":0.005534351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01540546951335721,"score_gpt":0.2148331883477886,"score_spread":0.1994277188344313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}