{"id":"W4297518689","doi":"10.1097/aln.0000000000004389","title":"Local Anesthetic Cardiac Toxicity Is Mediated by Cardiomyocyte Calcium Dynamics","year":2022,"lang":"en","type":"article","venue":"Anesthesiology","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Assembly of First Nations; University of Toronto","funders":"","keywords":"Medicine; Cardiac toxicity; Calcium; Toxicity; Anesthetic; Cardiology; Pharmacology; Anesthesia; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002305958,0.0002725023,0.0002295695,0.0001298809,0.0001194772,0.0003373088,0.0001950628,0.0002096489,0.0008189697],"category_scores_gemma":[0.0002088415,0.000100988,0.0002252013,0.00008157003,0.0002603008,0.0001955645,0.0001839857,0.0003615621,0.0001304287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002432479,"about_ca_system_score_gemma":0.00015813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002075466,"about_ca_topic_score_gemma":0.0003453126,"domain_scores_codex":[0.9998199,0.00002938781,0.00001847152,0.00004046975,0.00006215651,0.0000295851],"domain_scores_gemma":[0.9997656,0.00004157939,0.0001146195,0.00002356789,0.00003249625,0.00002210699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001390508,0.00001770315,0.0007137465,0.00003620513,0.000007965659,0.00003027369,0.00001094005,0.00005163641,0.9970689,0.00003963147,0.00002121914,0.001862674],"study_design_scores_gemma":[0.00003469418,0.001233042,0.03757207,0.00002093911,0.00007103354,0.0003104441,0.00006162503,0.001427691,0.958235,0.00007908744,0.0009487214,0.000005544566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934635,0.002391302,0.002761844,0.0001210194,0.00001361191,0.00002853509,0.00009568004,0.00003245111,0.001092155],"genre_scores_gemma":[0.9972029,0.00118392,0.001017617,0.00004808711,0.000008227534,0.00003349934,0.0000667342,0.000005638068,0.0004334488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008189697,"threshold_uncertainty_score":0.002739727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01965956760640379,"score_gpt":0.2405447025191344,"score_spread":0.2208851349127306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}