{"id":"W4297519309","doi":"10.2337/db21-1065","title":"Dynamic <i>Ins2</i> Gene Activity Defines β-Cell Maturity States","year":2022,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Breakthrough T1D Canada; Canadian Institutes of Health Research","keywords":"Biology; Insulin; Endoplasmic reticulum; Cell; Cell biology; Context (archaeology); Endocrinology; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002149619,0.0001842198,0.0003487094,0.0001154856,0.0002443221,0.00002343267,0.00009854073,0.00004476766,0.001057362],"category_scores_gemma":[0.00007142925,0.0001708476,0.0001299268,0.0002766598,0.00006067877,0.00007551129,0.0001293276,0.0002731499,0.0001037268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001136448,"about_ca_system_score_gemma":0.0000755529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002158384,"about_ca_topic_score_gemma":6.348424e-7,"domain_scores_codex":[0.9987262,0.00008630419,0.0001694916,0.0003095264,0.0003245519,0.000383957],"domain_scores_gemma":[0.9991919,0.0001814535,0.00008219157,0.0003450618,0.00004853293,0.0001507946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001132325,0.0009715325,0.2101114,0.0003022908,0.0001160125,0.00002177993,0.0001542936,0.0001061654,0.7709245,0.00006148699,0.01325879,0.003858496],"study_design_scores_gemma":[0.00421412,0.0009833672,0.1216465,0.00004321734,0.0003731166,0.00001638355,0.0003701052,0.01477774,0.7970579,0.001210457,0.05861347,0.0006936594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990948,0.001783792,0.0000142946,0.0008742606,0.000376918,0.0002453954,0.0001447192,0.0002119134,0.005400711],"genre_scores_gemma":[0.9934502,0.00007855039,0.0005976972,0.002268534,0.00004508905,0.0001249425,0.0002322204,0.00003232724,0.003170418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08846495,"threshold_uncertainty_score":0.9998558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007821499785214318,"score_gpt":0.2231015616792665,"score_spread":0.2152800618940522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}