{"id":"W4297519309","doi":"10.2337/db21-1065","title":"Dynamic <i>Ins2</i> Gene Activity Defines β-Cell Maturity States","year":2022,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Breakthrough T1D Canada; Canadian Institutes of Health Research","keywords":"Biology; Insulin; Endoplasmic reticulum; Cell; Cell biology; Context (archaeology); Endocrinology; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001863028,0.0001964121,0.0002276551,0.0003114049,0.0001083406,0.0005897074,0.0001297084,0.0002050089,0.001083812],"category_scores_gemma":[0.0001834591,0.0001159555,0.0001755854,0.0002849835,0.0002420809,0.0003147169,0.0001866645,0.0003908342,0.0002557059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002396631,"about_ca_system_score_gemma":0.0001000288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003255534,"about_ca_topic_score_gemma":0.0004479213,"domain_scores_codex":[0.9999119,0.000007771847,0.000006260579,0.00003436843,0.00002131551,0.00001830987],"domain_scores_gemma":[0.9998549,0.00003018184,0.0000461344,0.00001584941,0.00002197877,0.00003097095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007753455,0.000008190245,0.002147201,0.00001440192,0.000003081473,0.0000202785,0.00002509147,0.00005083284,0.9964612,0.00008395829,0.00002776869,0.001080391],"study_design_scores_gemma":[0.000008026152,0.0001599593,0.1235941,0.000009663678,0.0000194602,0.0003421978,0.0001414844,0.002357491,0.8710601,0.0002325158,0.002061343,0.00001377414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896649,0.0007333528,0.007477587,0.0000476908,0.00001004576,0.00001234688,0.0005580605,0.00007951769,0.001416555],"genre_scores_gemma":[0.9952839,0.0003874279,0.002827426,0.00005655573,0.00001026769,0.00002560926,0.0006049954,0.00005002372,0.0007536897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001083812,"threshold_uncertainty_score":0.003625751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007821499785214318,"score_gpt":0.2231015616792665,"score_spread":0.2152800618940522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}